Tyrrell Kerin L, Citron Diane M, Jenkins Jeffrey R, Goldstein Ellie J C
R.M. Alden Research Laboratory, UCLA/Santa Monica Medical Center, Santa Monica, California 90404, USA.
J Clin Microbiol. 2002 Mar;40(3):1044-7. doi: 10.1128/JCM.40.3.1044-1047.2002.
Despite the high incidence of odontogenic abscesses in pet rabbits, published data on the bacteriology of these infections are lacking, and clinical cultures are often ambiguous, making antibiotic choices difficult. In order to define the bacteriology of these infections, 12 rabbit mandibular and maxillary abscesses were cultured aerobically and anaerobically. All specimens yielded pathogenic bacteria, including Fusobacterium nucleatum, Prevotella heparinolytica, Prevotella spp., Peptostreptococcus micros, Streptococcus milleri group, Actinomyces israelii, and Arcanobacterium haemolyticum. These organisms are consistent with the characterized bacteriology of periodontal disease in human and other mammalian studies. The isolates were tested against 10 antimicrobial agents commonly used to treat rabbits; 100% of the strains tested were susceptible to clindamycin, 96% were susceptible to penicillin and ceftriaxone, 54% were susceptible to ciprofloxacin, and only 7% were susceptible to trimethoprim-sulfamethoxazole.
尽管宠物兔牙源性脓肿的发病率很高，但关于这些感染的细菌学的已发表数据却很缺乏，而且临床培养结果往往不明确，这使得抗生素的选择变得困难。为了明确这些感染的细菌学特征，对12例兔下颌和上颌脓肿进行了需氧和厌氧培养。所有标本均培养出病原菌，包括具核梭杆菌、解肝素普雷沃菌、普雷沃菌属、微小消化链球菌、米勒链球菌组、衣氏放线菌和溶血隐秘杆菌。这些微生物与人类和其他哺乳动物研究中已明确的牙周病细菌学特征一致。对分离出的菌株进行了10种常用于治疗兔子的抗菌药物测试；100%的测试菌株对克林霉素敏感，96%对青霉素和头孢曲松敏感，54%对环丙沙星敏感，只有7%对甲氧苄啶-磺胺甲恶唑敏感。
