Jha Anand M, Bharti Mithilesh K
Department of Botany and Biotechnology, Genetic Toxicology Laboratory, Samastipur College, Samastipur, Bihar 848 134, India.
Mutat Res. 2002 Mar 20;500(1-2):97-101. doi: 10.1016/s0027-5107(01)00303-7.
Mutagenic effect of carbazole was evaluated by employing dominant lethal mutation and sperm head abnormality assays in male Swiss albino mice. For the dominant lethal mutation assay, adult male mice were treated for five consecutive days either with 30 or 60 mg/kg body weight (b.w.) of carbazole by single intraperitoneal (i.p.) injection. For the sperm head abnormality assay mice were treated with 50, 100, 150, 200 and 300 mg/kg b.w as a single i.p. injection. Treatment of adult male mice with carbazole resulted in induction of dominant lethal mutation and abnormal sperm heads. The results show that carbazole is mutagenic in male germ cells of mice.
通过在雄性瑞士白化小鼠中采用显性致死突变和精子头部异常试验，评估咔唑的诱变作用。对于显性致死突变试验，成年雄性小鼠通过单次腹腔注射，连续五天接受30或60毫克/千克体重的咔唑处理。对于精子头部异常试验，小鼠以50、100、150、200和300毫克/千克体重的剂量单次腹腔注射。用咔唑处理成年雄性小鼠导致显性致死突变和精子头部异常。结果表明，咔唑对小鼠雄性生殖细胞具有诱变作用。
