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基因排列的精妙艺术：基因簇的意义

The gentle art of gene arrangement: the meaning of gene clusters.

作者信息

Trowsdale John

机构信息

Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK.

出版信息

Genome Biol. 2002;3(3):COMMENT2002. doi: 10.1186/gb-2002-3-3-comment2002. Epub 2002 Feb 22.

DOI:10.1186/gb-2002-3-3-comment2002
PMID:11897017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC139018/
Abstract

Genome sequence comparisons reveal that some sets of genes are in similar linkage groups in different organisms while other sets are dispersed. Are some linkage groups maintained by chance, or is there an advantage to such an arrangement? Some insights may come from large clusters of genes, such as the major histocompatibility complex which includes many genes involved in immune defense.

摘要

基因组序列比较显示，在不同生物体中，有些基因集处于相似的连锁群中，而其他基因集则是分散的。这些连锁群是偶然维持的，还是这种排列有某种优势呢？一些见解可能来自基因的大簇，比如主要组织相容性复合体，它包含许多参与免疫防御的基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c0e/139018/c4a84d006455/gb-2002-3-3-comment2002-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c0e/139018/c4a84d006455/gb-2002-3-3-comment2002-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c0e/139018/c4a84d006455/gb-2002-3-3-comment2002-1.jpg

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