Jones A M, Govan J R, Doherty C J, Dodd M E, Isalska B J, Stanbridge T N, Webb A K
Lancet. 2001 Aug 18;358(9281):557-8. doi: 10.1016/s0140-6736(01)05714-2.
We initiated a prospective surveillance study to investigate possible Pseudomonas aeruginosa cross-infection in our cystic fibrosis centre. We characterised isolates by pyocin typing and pulsed-field gel electrophoresis. 22 (14%) of 154 patients with chronic P aeruginosa had isolates with similar and new pyocin and pulsed-field gel electrophoresis types. The shared isolates showed unusual phenotypic features: they were non-pigmented, non-motile, and resistant to a number of antipseudomonal antibiotics. Cross-infection by a multiresistant P aeruginosa strain has therefore occurred in patients attending our cystic fibrosis centre. We recommend microbiological surveillance in other cystic fibrosis centres.
我们开展了一项前瞻性监测研究，以调查在我们的囊性纤维化中心可能存在的铜绿假单胞菌交叉感染情况。我们通过绿脓菌素分型和脉冲场凝胶电泳对分离菌株进行了特征分析。154例慢性铜绿假单胞菌感染患者中有22例（14%）的分离菌株具有相似的以及新的绿脓菌素和脉冲场凝胶电泳类型。这些共享的分离菌株表现出不同寻常的表型特征：它们无色素、无运动性，并且对多种抗假单胞菌抗生素耐药。因此，在我们囊性纤维化中心就诊的患者中发生了多重耐药铜绿假单胞菌菌株的交叉感染。我们建议其他囊性纤维化中心开展微生物监测。
