mar操纵子与产气肠杆菌的多药耐药性有关。
mar Operon involved in multidrug resistance of Enterobacter aerogenes.
作者信息
Chollet Renaud, Bollet Claude, Chevalier Jacqueline, Malléa Monique, Pagès Jean-Marie, Davin-Regli Anne
机构信息
Enveloppe Bactérienne, Antibiotiques et Colonisation, CJF 9606-EA 2197, Facultés de Médecine et Pharmacie, Université de la Méditerranée, 13385 Marseille Cedex 05, France.
出版信息
Antimicrob Agents Chemother. 2002 Apr;46(4):1093-7. doi: 10.1128/AAC.46.4.1093-1097.2002.
Abstract
We determined the sequence of the entire marRAB operon in Enterobacter aerogenes. It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin.
摘要
我们测定了产气肠杆菌中整个marRAB操纵子的序列。它在功能和结构上与大肠杆菌操纵子相似。产气肠杆菌MarA的过表达在敏感菌株中诱导出多药耐药表型，表现为对多种抗生素有明显抗性、免疫检测到的孔蛋白减少以及诺氟沙星的主动外排。
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本文引用的文献
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Absence of mutations in marRAB or soxRS in acrB-overexpressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli.在过表达acrB的耐氟喹诺酮类临床和兽医源大肠杆菌分离株中，marRAB或soxRS未发生突变。
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