Narisawa T, Wong C Q, Weisburger J H
Am J Dig Dis. 1975 Oct;20(10):928-34. doi: 10.1007/BF01070878.
This study is an evaluation of the use of endoscopic examination to detect MNNG-induced large-bowel tumors in rats. The smallest human fiberbronchoscope was used as a colonoscope for the rats and the full length of the distal large bowel was visualized. The correct diagnosis rate in all rats with and without large-bowel tumors was 94%. Of rats with colon tumors, 85% were correctly diagnosed endoscopically. Even tumors 1 or 2 mm in diameter were detected. The examination was easy and reliable. This procedure may be an adjunct in experimental work with this and other animal models of colon cancer.
本研究旨在评估使用内镜检查来检测N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导的大鼠大肠肿瘤。将最小的人类纤维支气管镜用作大鼠的结肠镜，对远端大肠的全长进行可视化观察。所有有或无大肠肿瘤的大鼠的正确诊断率为94%。在患有结肠肿瘤的大鼠中，85%通过内镜检查得到正确诊断。甚至直径为1或2毫米的肿瘤也能被检测到。该检查简便且可靠。此方法可能是在这种及其他结肠癌动物模型的实验工作中的一种辅助手段。
