Karetzky M S
Am Rev Respir Dis. 1975 Nov;112(5):607-13. doi: 10.1164/arrd.1975.112.5.607.
Arterial and venous blood samples were obtained from 23 patients with acute asthma before they received systemic or intermittent positive-pressure breathing therapy. Serum lactate, electrolyte, and enzyme concentrations, arterial pH, arterial PCO2, arterial PO2, peak expiratory flows, and 2,3-diphosphoglycerate concentrations were measured. The serum glutamic oxaloacetic transaminase, lactic dehydrogenase, and creatine phosphokinase activities were increased in 90, 81, and 38 per cent of the patients, respectively, and the individual values correlated poorly with the arterial PO2. In addition, there was a close correlation between the 2,3-diphosphoglycerate concentration and arterial PO2 (r = -0.75), indicating an active intraerythrocytic compensatory mechanism for enhancing O2 delivery operative in acute asthma.
在23例急性哮喘患者接受全身或间歇性正压呼吸治疗前，采集其动脉血和静脉血样本。测定血清乳酸、电解质、酶浓度、动脉血pH值、动脉血二氧化碳分压、动脉血氧分压、呼气峰值流速以及2,3 - 二磷酸甘油酸浓度。分别有90%、81%和38%的患者血清谷氨酸草酰乙酸转氨酶、乳酸脱氢酶和肌酸磷酸激酶活性升高，且个体值与动脉血氧分压相关性较差。此外，2,3 - 二磷酸甘油酸浓度与动脉血氧分压之间存在密切相关性（r = -0.75），表明急性哮喘时存在一种活跃的红细胞内代偿机制以增强氧输送。
