Shin Chan Young, Lee Woo Jong, Lee Eun Bang, Choi Eui Yul, Ko Kwang Ho
Department of Pharmacology, College of Pharmacy, Seoul National University, Seoul, Korea.
Planta Med. 2002 Mar;68(3):221-5. doi: 10.1055/s-2002-23130.
The root of Platycodon grandiflorum has been widely used for the treatment of various chronic inflammatory diseases including airway disease in oriental medicine. The root extract of the plant has been known to be effective in the expectoration of sputum or mucus, thereby improving airway respiratory function and preventing secondary airway inflammation. In this study, we investigated the effect of platycodin D and D3, the saponin components that are anti-inflammatory components in Platycodon grandiflorum. Platycodin D and D3 increased mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization. The effect of platycodin D3 was stronger than that of ATP, a potent mucin secretagogue and also of ambroxole, a mucolytic drug. The results from the present study suggest that platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases.
桔梗根在东方医学中已被广泛用于治疗包括气道疾病在内的各种慢性炎症性疾病。已知该植物的根提取物在祛痰或黏液方面有效，从而改善气道呼吸功能并预防继发性气道炎症。在本研究中，我们研究了桔梗皂苷D和D3的作用，它们是桔梗中的抗炎皂苷成分。桔梗皂苷D和D3可增加大鼠和仓鼠气管表面上皮细胞培养物中黏蛋白的释放，雾化时也可增加完整大鼠气管中黏蛋白的释放。桔梗皂苷D3的作用强于强效黏蛋白促分泌剂ATP以及黏液溶解药物氨溴索。本研究结果表明，桔梗皂苷D和D3可作为祛痰剂用于治疗各种气道疾病。
