Leshner A I, Remler H, Biegon A, Samuel D
Psychopharmacology (Berl). 1979 Nov;66(2):207-8. doi: 10.1007/BF00427633.
In a study of the mechanisms controlling the learned helplessness phenomenon, rats were exposed to either inescapable preshocks or control procedures, treated with one of three dosages of desmethylimipramine, and tested for later adaptive responding. This catecholamine modulator attenuated the deficits in escape responding that ordinarily follow prior exposure to inescapable preshocks, and it did so in a dose-dependent fashion. These findings support the position that the learned helplessness phenomenon is mediated by catecholamine changes.
在一项关于控制习得性无助现象机制的研究中，将大鼠暴露于不可逃避的预电击或对照程序下，用三种剂量之一的去甲丙咪嗪进行处理，并测试其随后的适应性反应。这种儿茶酚胺调节剂减轻了通常在先前暴露于不可逃避的预电击后出现的逃避反应缺陷，并且是以剂量依赖的方式做到的。这些发现支持了习得性无助现象是由儿茶酚胺变化介导的这一观点。
