Abdala N, Levitin A, Dawson A, Maffra R, Munoz-Ramirez H, Godec K, Dolmatch B L
Department of Radiology, University of Sao Paulo, Sao Paulo, Brazil.
J Vasc Interv Radiol. 2001 Aug;12(8):979-84. doi: 10.1016/s1051-0443(07)61579-6.
To assess the efficacy of ethylene vinyl alcohol copolymer (Uryx) in nonsurgically occluding the fallopian tube and achieving tubal sterilization in the rabbit model.
Ten mature virgin female New England rabbits underwent transvaginal selective bilateral fallopian tube cannulation with use of a coaxial catheter system under general anesthesia. Selective salpingography was performed bilaterally to assess patency of the fallopian tubes. Ethylene vinyl alcohol copolymer was injected unilaterally through a microcatheter to completely fill the middle portion of the tube. Three to seven days after injection, each animal was bred. Conception was determined by ultrasonography (US) 7-19 days after effective breeding. If pregnant, the rabbit was killed. Otherwise, it was permitted to rebreed until pregnancy was achieved. Histologic specimens of the fallopian tubes were prepared and analyzed.
Patency of the fallopian tubes was demonstrated bilaterally in all animals by the free spillage of contrast material into the peritoneum. The delivery of ethylene vinyl alcohol copolymer into the fallopian tubes was successful in all animals but one, in which most of the plug almost immediately extruded into the uterus. Pregnancy was detected by US in the untreated fallopian tube in the nine rabbits that were receptive to breeding. No pregnancies were detected in the injected side. Histologic analysis demonstrated variable degrees of occlusion, fibrosis, and inflammation, with the majority of specimens demonstrating mild to moderate inflammation and moderate to marked fibrosis.
Ethylene vinyl alcohol copolymer can reliably be placed nonsurgically via the transvaginal approach into the fallopian tubes with use of a coaxial catheter system. Ethylene vinyl alcohol copolymer appears to result in less fibrosis than previously investigated agents and demonstrates a 100% early sterilization rate in the rabbit model.
评估乙烯-乙烯醇共聚物（Uryx）在兔模型中通过非手术方式闭塞输卵管并实现输卵管绝育的疗效。
10只成熟未孕的雌性新西兰兔在全身麻醉下使用同轴导管系统经阴道进行双侧选择性输卵管插管。双侧进行选择性输卵管造影以评估输卵管通畅情况。通过微导管单侧注入乙烯-乙烯醇共聚物以完全填充输卵管中部。注射后3至7天，每只动物进行交配。在有效交配后7 - 19天通过超声检查（US）确定是否受孕。如果怀孕，兔子处死。否则，允许其再次交配直至怀孕。制备并分析输卵管的组织学标本。
所有动物双侧输卵管造影均显示造影剂自由溢入腹腔，表明输卵管通畅。除一只动物外，所有动物向输卵管内注入乙烯-乙烯醇共聚物均成功，该动物大部分栓塞几乎立即挤出至子宫内。在9只接受交配的兔子中，未处理侧的输卵管经超声检查发现怀孕。注入侧未检测到怀孕。组织学分析显示不同程度的闭塞、纤维化和炎症，大多数标本表现为轻度至中度炎症和中度至重度纤维化。
使用同轴导管系统，乙烯-乙烯醇共聚物可通过经阴道途径可靠地非手术置入输卵管。与先前研究的药物相比，乙烯-乙烯醇共聚物似乎导致的纤维化更少，并且在兔模型中显示出100%的早期绝育率。
