Maubon A, Rouanet J P, Laurent A, Joujoux J M, Cover S, Courtieu C, Wassef M, Godlewski G, Honiger J, Lopez F M
Imagerie Medicale, C.M.C. Beausoleil, Montpellier, France.
Invest Radiol. 1994 Feb;29(2):156-61. doi: 10.1097/00004424-199402000-00007.
The feasibility of tubal occlusion by selective salpingography was tested in an animal model; three novel occluding materials also were tested for this application.
Unilateral selective salpingography was performed in three groups of six rabbits; fallopian tubes were embolized with ethanol (group 1), a hydrogel (group 2), or an occluding emulsion (Ethibloc, Laboratoire Princeps, Neuilly sur Seine, France) (group 3). Animals were killed 2 days or 30 days after the procedure, according to randomization; tubal patency and histologic modifications were evaluated.
Selective tubal catheterization was obtained in 100% of the cases. In group 1, no satisfactory occlusion was obtained; in group 2, 65% of the tubes were occluded with little histologic damage; in group 3, 80% of the tubes were occluded, but significant inflammation and tissue necrosis were noted.
Selective salpingography proved a suitable method for gaining access to the fallopian tube and allowed selective injection of occluding materials. More research is needed to determine a suitable occluding material, focusing on biocompatibility and on long-term efficacy.
在动物模型中测试选择性输卵管造影术进行输卵管阻塞的可行性；还针对此应用测试了三种新型阻塞材料。
对三组每组六只兔子进行单侧选择性输卵管造影术；输卵管分别用乙醇栓塞（第1组）、水凝胶（第2组）或阻塞性乳剂（Ethibloc，法国巴黎塞纳河畔讷伊市Princeps实验室）栓塞（第3组）。根据随机分组，在术后2天或30天处死动物；评估输卵管通畅情况和组织学改变。
100%的病例成功进行了选择性输卵管插管。第1组未获得满意的阻塞效果；第2组65%的输卵管被阻塞，组织学损伤较小；第3组80%的输卵管被阻塞，但出现了明显的炎症和组织坏死。
选择性输卵管造影术被证明是一种进入输卵管的合适方法，并允许选择性注射阻塞材料。需要更多研究来确定合适的阻塞材料，重点关注生物相容性和长期疗效。
