D'Souza Prashanth, Deepak Mundkinajeddu, Rani Padmaja, Kadamboor Sandhya, Mathew Anjana, Chandrashekar Arun P, Agarwal Amit
Bioassay Unit, M/s Natural Remedies Pvt Ltd, 5B Veerasandra Indl Area, Hosur Road, Bangalore 561 229, India.
Phytother Res. 2002 Mar;16(2):197-8. doi: 10.1002/ptr.1001.
Successive petroleum ether, chloroform, ethanol and water extracts, a saponin rich fraction (SRF) and bacoside A isolated from Bacopa monnieri were tested for brine shrimp lethality. Successive ethanol extracts and SRF showed potent activity. Bacoside A showed the maximum activity with a LC(50) of 38.3 microg/mL. The results confirmed the previous reports of an anticancer effect of Bacopa monnieri and suggest bacoside A as the active constituent.
