Abiola Oduola O, Iyegbe Conrad, Lantos Peter, Plomin Robert, Anderton Brian H, Whatley Stephen A
Department of Neuroscience, Genetic and Developmental Psychiatry Research Centre, KCL Institute of Psychiatry, London, UK.
Intervirology. 2002;45(1):56-8. doi: 10.1159/000050088.
Four strains of mice were inoculated intracerebrally with a primary isolate of bovine spongiform encephalopathy (BSE) and the cloned mouse-adapted scrapie strain ME7. Clinical prion disease diagnosis was made at the appearance of three or more neurological symptoms and their persistence for 3 consecutive weeks and confirmed by neuropathological criteria. For BSE, incubation periods were profoundly different between the sexes in all four mouse strains, being longer in the females. In contrast, ME7 scrapie incubation times were similar between the sexes. Our results indicate that sex-specific processes are involved in the course of primary BSE transmission. Research into this phenomenon may provide clues to the prophylaxis of BSE and have possible implications for new variant Creutzfeldt-Jakob disease in humans.
将四株小鼠脑内接种牛海绵状脑病（BSE）的原始分离株以及克隆的适应小鼠的瘙痒病株ME7。当出现三种或更多种神经症状且持续3周时作出临床朊病毒病诊断，并通过神经病理学标准进行确认。对于BSE，在所有四株小鼠品系中，两性之间的潜伏期差异极大，雌性的潜伏期更长。相比之下，ME7瘙痒病的潜伏期在两性之间相似。我们的结果表明，性别特异性过程参与了原发性BSE传播过程。对这一现象的研究可能为BSE的预防提供线索，并可能对人类新变异型克雅氏病产生影响。
