Fogari Roberto, Zoppi Annalisa, Preti Paola, Rinaldi Andrea, Marasi Gianluigi, Vanasia Alessandro, Mugellini Amedeo
Department of Internal Medicine and Therapeutics, Clinica Medica, IRCCS Policlinico S. Matteo, University of Pavia, Italy.
Am J Hypertens. 2002 Mar;15(3):217-21. doi: 10.1016/s0895-7061(01)02280-4.
The aim of this study was to compare sexual activity and plasma testosterone levels of hypertensive men with those of healthy normotensive controls. We investigated 110 newly diagnosed, never treated hypertensive (blood pressure [BP] > or = 140/95 mm Hg) men and 110 healthy normotensive (diastolic BP <90 mm Hg) men. All of them were aged 40 to 49 years, married, without any previous sexual dysfunction, nondiabetic, nonobese (body mass index <28 kg/m2), nonsmoking, and not taking any drug. All subjects were evaluated in the morning after an overnight fast. Clinical evaluation included BP, body weight, and height measurements, determination of testosterone, and an interview about sexual activity, assessed as number of sexual intercourse episodes per month. Hypertensive men presented a 25% reduction in sexual activity as compared to normotensive men (5.9 +/- 2.6 v 7.9 +/- 2.5 sexual intercourse episodes per month, respectively, P < .01) and a 12% reduction in testosterone levels (510.6 +/- 151.9 ng/dL v 578.6 +/- 146.8 ng/dL, P < .01). In both normotensive and hypertensive men Pearson's correlation analysis showed a significant positive correlation between testosterone levels and sexual activity and a significant negative correlation between testosterone and age and between testosterone and BP values. Multiple regression analysis confirmed a significant inverse relationship between testosterone and age in normotensive men, whereas only a nonsignificant trend was found in the hypertensive ones. In addition, a significant inverse correlation between testosterone and BP levels was confirmed in hypertensive men limited to systolic BP, whereas a nonsignificant trend was observed in the normotensive controls. In conclusion, these findings suggest a relationship between essential hypertension and impaired testosterone levels in men. The elucidation of the nature of such a relationship and its physiologic and clinical significance needs further investigation.
本研究旨在比较高血压男性与健康血压正常对照者的性活动及血浆睾酮水平。我们调查了110名新诊断的、从未接受过治疗的高血压（血压[BP]≥140/95 mmHg）男性和110名健康血压正常（舒张压<90 mmHg）男性。他们均年龄在40至49岁之间，已婚，既往无任何性功能障碍，非糖尿病患者，非肥胖（体重指数<28 kg/m²），不吸烟，且未服用任何药物。所有受试者均在禁食过夜后的早晨进行评估。临床评估包括血压、体重和身高测量、睾酮测定，以及关于性活动的访谈，性活动以每月性交次数进行评估。与血压正常的男性相比，高血压男性的性活动减少了25%（分别为每月5.9±2.6次与7.9±2.5次性交，P<.01），睾酮水平降低了12%（510.6±151.9 ng/dL与578.6±146.8 ng/dL，P<.01）。在血压正常和高血压男性中，Pearson相关分析均显示睾酮水平与性活动之间存在显著正相关，睾酮与年龄以及睾酮与血压值之间存在显著负相关。多元回归分析证实，血压正常男性中睾酮与年龄之间存在显著负相关，而在高血压男性中仅发现不显著的趋势。此外，在高血压男性中，仅收缩压与睾酮水平之间存在显著负相关，而在血压正常对照者中观察到不显著的趋势。总之，这些发现提示原发性高血压与男性睾酮水平受损之间存在关联。阐明这种关系的性质及其生理和临床意义需要进一步研究。
