Pintana Hiranya, Chattipakorn Nipon, Chattipakorn Siriporn
Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Metab Brain Dis. 2015 Aug;30(4):853-76. doi: 10.1007/s11011-015-9655-3. Epub 2015 Feb 24.
Testosterone is an androgenic steroid hormone, which plays an important role in the regulation of male reproduction and behaviors, as well as in the maintenance of insulin sensitivity. Several studies showed that testosterone exerted beneficial effects in brain function, including preventing neuronal cell death, balancing brain oxidative stress and antioxidant activity, improving synaptic plasticity and involving cognitive formation. Although previous studies showed that testosterone deficiency is positively correlated with cognitive impairment and insulin-resistant obesity, several studies demonstrated contradictory findings. Thus, this review comprehensively summarizes the current evidence from in vitro, in vivo and clinical studies of the relationship between testosterone deficiency and insulin-resistant obesity as well as the correlation between either insulin-resistant obesity or testosterone deficiency and cognitive impairment. Controversial reports and the mechanistic insights regarding the roles of testosterone in insulin-resistant obesity and cognitive function are also presented and discussed.
睾酮是一种雄激素类固醇激素，在男性生殖和行为的调节以及胰岛素敏感性的维持中发挥重要作用。多项研究表明，睾酮对脑功能具有有益作用，包括预防神经元细胞死亡、平衡脑氧化应激和抗氧化活性、改善突触可塑性以及参与认知形成。尽管先前的研究表明睾酮缺乏与认知障碍和胰岛素抵抗性肥胖呈正相关，但也有多项研究得出了相互矛盾的结果。因此，本综述全面总结了目前来自体外、体内和临床研究的证据，这些证据涉及睾酮缺乏与胰岛素抵抗性肥胖之间的关系，以及胰岛素抵抗性肥胖或睾酮缺乏与认知障碍之间的相关性。此外，还介绍并讨论了关于睾酮在胰岛素抵抗性肥胖和认知功能中作用的有争议的报告及机制见解。
