Huettel Scott A, Mack Peter B, McCarthy Gregory
Brain Imaging and Analysis Center, Box 3918, Duke University Medical Center, Durham, North Carolina 27710, USA.
Nat Neurosci. 2002 May;5(5):485-90. doi: 10.1038/nn841.
We demonstrate that regions within human prefrontal cortex develop moment-to-moment models for patterns of events occurring in the sensory environment. Subjects viewed a random binary sequence of images, each presented singly and each requiring a different button press response. Patterns occurred by chance within the presented series of images. Using functional magnetic resonance imaging (fMRI), we identified activity evoked by viewing a stimulus that interrupted a pattern. Prefrontal activation was evoked by violations of both repeating and alternating patterns, and the amplitude of this activation increased with increasing pattern length. Violations of repeating patterns, but not of alternating patterns, activated the basal ganglia.
我们证明，人类前额叶皮质内的区域会针对感觉环境中发生的事件模式构建即时模型。受试者观看一系列随机的二元图像序列，每个图像单独呈现，且每个图像都需要不同的按键响应。在所呈现的图像序列中，模式是随机出现的。使用功能磁共振成像（fMRI），我们识别出观看中断模式的刺激所诱发的活动。重复模式和交替模式的违反都会诱发前额叶激活，并且这种激活的幅度会随着模式长度的增加而增大。重复模式的违反会激活基底神经节，但交替模式的违反则不会。
