Steer Peter, Millgård Jonas, Sarabi Dennis M, Basu Samar, Vessby Bengt, Kahan Thomas, Edner Magnus, Lind Lars
Department of Medical Sciences/Internal Medicine, University Hospital, Uppsala, Sweden.
Lipids. 2002 Mar;37(3):231-6. doi: 10.1007/s11745-002-0885-3.
The present study investigated possible relationships between left ventricular mass, intima-media thickness of the carotid artery (IMT), total arterial compliance, and lipid status in a population sample of 58 apparently healthy subjects aged 20 to 69. By stepwise multiple regression analysis, including age, blood pressure, and smoking, left ventricular mass index, measured by M-mode echocardiography, increased by 13.0 g/m2 for each 1 standard deviation (SD = 0.11 microM, r = 0.60, P< 0.01) increase in plasma malondialdehyde and 9.50 g/m2 per SD increase in plasma 8-iso-prostaglandin F2alpha in women only (SD = 8.88 ng/L, r = 0.44, P = 0.01). Each 1-SD (SD = 0.27 g/L) increase in apolipoprotein B was associated with a 63 microm increase in IMT (r = 0.47, P = 0.014) and a 0.27 mL/min/m2/mm Hg (r = -0.60, P < 0.01) decrease in stroke index/pulse pressure ratio, reflecting total arterial compliance in women. In men, each 1-SD increase in the proportion of stearic acid (18:0) in serum cholesterol esters (SD = 0.12 percent units) reduced the transmitral E/A ratio, measured by Doppler echocardiography, reflecting left ventricular diastolic function, by 0.10 units (r = -0.29, P < 0.05). Thus, important cardiovascular characteristics, such as left ventricular mass, left ventricular diastolic function, carotid IMT, and total arterial compliance, were independently predicted by indices of lipid metabolism and peroxidation in apparently healthy subjects.
本研究在58名年龄在20至69岁之间的明显健康受试者的人群样本中，调查了左心室质量、颈动脉内膜中层厚度（IMT）、总动脉顺应性和血脂状况之间可能存在的关系。通过逐步多元回归分析，纳入年龄、血压和吸烟因素，采用M型超声心动图测量的左心室质量指数，在女性中，血浆丙二醛每增加1个标准差（SD = 0.11微摩尔/升，r = 0.60，P<0.01），左心室质量指数增加13.0克/平方米；血浆8-异前列腺素F2α每增加1个标准差（SD = 8.88纳克/升，r = 0.44，P = 0.01），左心室质量指数增加9.50克/平方米。载脂蛋白B每增加1个标准差（SD = 0.27克/升），与IMT增加63微米（r = 0.47，P = 0.014）以及反映女性总动脉顺应性的每搏输出量指数/脉压比值降低0.27毫升/分钟/平方米/毫米汞柱（r = -0.60，P < 0.01）相关。在男性中，血清胆固醇酯中硬脂酸（18:0）比例每增加1个标准差（SD = 0.12个百分点），通过多普勒超声心动图测量的反映左心室舒张功能的二尖瓣E/A比值降低0.10个单位（r = -0.29，P < 0.05）。因此，在明显健康的受试者中，脂质代谢和过氧化指标可独立预测重要的心血管特征，如左心室质量、左心室舒张功能、颈动脉IMT和总动脉顺应性。
