Gupta A K, Bluhm R, Summerbell R
Department of Medicine, Sunnybrook and Women's College Health Science Center, Toronto, Ontario, Canada.
J Eur Acad Dermatol Venereol. 2002 Jan;16(1):19-33. doi: 10.1046/j.1468-3083.2002.00378.x.
Pityriasis versicolor is a common superficial fungal infection of the skin. It is caused by Malassezia spp., which are normal human saprophytes. Under certain conditions, both exogenous and endogenous, the fungus can convert from a yeast to a pathogenic mycelial form. This alteration results in mild inflammation of the skin, and in characteristic clinical and histological changes. The taxonomy of Malassezia spp. has recently been modified to include six obligatorily lipophilic species, all of which can be found on human skin, plus one non-obligatorily lipophilic species, which only rarely colonizes human hosts.
At the conclusion of this learning activity, participants should be aware of the role of Malassezia in the development of pityriasis versicolor, the clinical and histological changes arising from this dermatosis, and the diagnosis and treatment of this disorder.
花斑糠疹是一种常见的皮肤浅表真菌感染。它由马拉色菌属引起,马拉色菌属是人类正常的腐生菌。在某些外源性和内源性条件下,该真菌可从酵母形态转变为致病菌丝形态。这种转变导致皮肤轻度炎症,并出现特征性的临床和组织学变化。马拉色菌属的分类最近已被修订,包括六种 obligatorily lipophilic 物种,所有这些都可在人类皮肤上发现,加上一种 non-obligatorily lipophilic 物种,它很少定殖于人类宿主。
在本学习活动结束时,参与者应了解马拉色菌在花斑糠疹发病中的作用、这种皮肤病引起的临床和组织学变化以及该疾病的诊断和治疗。 (注:原文中“obligatorily lipophilic”和“non-obligatorily lipophilic”可能是专业术语,暂无法准确翻译其确切含义,可根据具体医学背景进一步确定准确译名)