Gupta Aditya K, Lyons Danika C A
University of Toronto, Department of Medicine , Toronto , Canada.
Expert Opin Pharmacother. 2014 Aug;15(12):1707-13. doi: 10.1517/14656566.2014.931373. Epub 2014 Jul 3.
Pityriasis versicolor (PV) is a superficial fungal infection caused by Malassezia species; a yeast that naturally colonizes on the skins surface. High efficacy rates are generally obtained with both topical and systemic treatments. However, recurrence rates following successful treatment remain high and there are no dosage guidelines available for administration of systemic antifungal agents that carry risks of adverse events.
This review focused on providing an overview of existing treatments for PV and an introduction to new treatments. A literature search was conducted using the search strategy, pityriasis versicolor OR tinea versicolor. Over the past decade, few new treatments have been introduced, but the efficacy and the dosing regimens of existing treatments have been systematically reviewed. The results of these reviews are discussed.
Existing topical and systemic agents are both effective treatments against PV. Previous dosage recommendations for systemic agents have been modified based on recent evidence elucidated in systematic reviews. However, the absence of standardized collection and reporting practices in clinical trials precludes any conclusions to be drawn regarding the efficacy and safety of topical and systemic agents in comparison or in concert with each other.
花斑糠疹（PV）是一种由马拉色菌属引起的浅表真菌感染；马拉色菌是一种自然定植于皮肤表面的酵母。局部和全身治疗通常都有较高的有效率。然而，成功治疗后的复发率仍然很高，并且对于有不良事件风险的全身用抗真菌药物，尚无给药剂量指南。
本综述着重于概述花斑糠疹的现有治疗方法并介绍新的治疗方法。采用“花斑糠疹或花斑癣”的检索策略进行文献检索。在过去十年中，几乎没有引入新的治疗方法，但对现有治疗方法的疗效和给药方案进行了系统评价。讨论了这些评价的结果。
现有的局部和全身用药都是治疗花斑糠疹的有效方法。基于系统评价中阐明的最新证据，对全身用药以前的剂量推荐进行了修改。然而，临床试验中缺乏标准化的收集和报告做法，无法就局部和全身用药相互比较或联合使用时的疗效和安全性得出任何结论。
