环氧化酶抑制：进退两难。
Cyclooxygenase inhibition: between the devil and the deep blue sea.
作者信息
Hawkey C J
机构信息
Queen's Medical Centre, University Hospital, Nottingham, UK.
出版信息
Gut. 2002 May;50 Suppl 3(Suppl 3):III25-30. doi: 10.1136/gut.50.suppl_3.iii25.
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) account for more reports of drug related toxicity than any other class of drugs. Their most widely recognised adverse effects are on the gastrointestinal tract. They cause acute erosions and chronic ulcers that result in hospitalisation and death because of ulcer bleeding and perforation. Between them, aspirin and non-aspirin NSAIDs may account for more than half of all episodes of ulcer bleeding and perforation.
摘要
与其他任何一类药物相比，非甾体抗炎药（NSAIDs）引发的药物相关毒性报告更多。它们最广为人知的不良反应是对胃肠道的影响。它们会导致急性糜烂和慢性溃疡，进而因溃疡出血和穿孔而导致住院和死亡。阿司匹林和非阿司匹林类NSAIDs加起来可能占所有溃疡出血和穿孔病例的一半以上。
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