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一株实验室衍生的、对氨苄西林高度耐药的鼠伤寒沙门氏菌菌株的特性分析，该菌株导致一名婴儿患脑膜炎。

Characterization of a laboratory-derived, high-level ampicillin-resistant Salmonella enterica serovar Typhimurium strain that caused meningitis in an infant.

作者信息

Chiu Cheng-Hsun, Chu Chishih, Su Lin-Hui, Wu Wan-Yu, Wu Tsu-Lan

机构信息

Department of Pediatrics, Chang Gung Children's Hospital, Kweishan 333, Taoyuan, Taiwan.

出版信息

Antimicrob Agents Chemother. 2002 May;46(5):1604-6. doi: 10.1128/AAC.46.5.1604-1606.2002.

DOI:10.1128/AAC.46.5.1604-1606.2002
PMID:11959613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC127154/
Abstract

A Salmonella enterica serovar Typhimurium strain that harbored a plasmid carrying a TEM-1-type beta-lactamase gene was isolated from the blood and cerebrospinal fluid of an infant with meningitis. This 3.2-kb plasmid was further characterized to be a nonconjugative pGEM series cloning vector containing a foreign insert. The strain was likely laboratory derived and contaminated the environment before it caused the infection.

摘要

从一名患脑膜炎婴儿的血液和脑脊液中分离出一株携带含有TEM-1型β-内酰胺酶基因质粒的肠炎沙门氏菌鼠伤寒血清型菌株。这个3.2kb的质粒经进一步鉴定为一个含有外源插入片段的非接合型pGEM系列克隆载体。该菌株很可能来源于实验室，在引起感染之前污染了环境。

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本文引用的文献

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Lack of evidence of an association between the carriage of virulence plasmid and the bacteremia of Salmonella typhimurium in humans.缺乏毒力质粒携带与人类鼠伤寒沙门氏菌菌血症之间存在关联的证据。
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Molecular investigation of two clusters of hospital-acquired bacteraemia caused by multi-resistant Klebsiella pneumoniae using pulsed-field gel electrophoresis and in frequent restriction site PCR. Infection Control Group.运用脉冲场凝胶电泳和稀有切割位点聚合酶链反应对两起由多重耐药肺炎克雷伯菌引起的医院获得性菌血症聚集病例进行分子研究。感染控制组
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5
Propagation of TEM- and PSE-type beta-lactamases among amoxicillin-resistant Salmonella spp. isolated in France.TEM型和PSE型β-内酰胺酶在法国分离出的耐阿莫西林沙门氏菌中的传播情况。
Antimicrob Agents Chemother. 1999 Oct;43(10):2430-6. doi: 10.1128/AAC.43.10.2430.
6
Rapid identification of Salmonella serovars in feces by specific detection of virulence genes, invA and spvC, by an enrichment broth culture-multiplex PCR combination assay.通过富集肉汤培养-多重聚合酶链反应联合检测法特异性检测毒力基因invA和spvC，快速鉴定粪便中的沙门氏菌血清型。
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7
DNA fingerprinting by infrequent-restriction-site amplification.通过稀有限制性酶切位点扩增进行DNA指纹分析。
J Clin Microbiol. 1996 Oct;34(10):2386-90. doi: 10.1128/jcm.34.10.2386-2390.1996.
8
Treatment of Salmonella gastroenteritis with ampicillin, amoxicillin, or placebo.用氨苄西林、阿莫西林或安慰剂治疗沙门氏菌肠胃炎。
Pediatrics. 1980 Jun;65(6):1125-30.
9
Rapid procedure for detection and isolation of large and small plasmids.用于检测和分离大小质粒的快速方法。
J Bacteriol. 1981 Mar;145(3):1365-73. doi: 10.1128/jb.145.3.1365-1373.1981.
10
The virulence plasmids of Salmonella serovars typhimurium, choleraesuis, dublin, and enteritidis, and the cryptic plasmids of Salmonella serovars copenhagen and sendai belong to the same incompatibility group, but not those of Salmonella serovars durban, gallinarum, give, infantis and pullorum.鼠伤寒沙门氏菌、猪霍乱沙门氏菌、都柏林沙门氏菌和肠炎沙门氏菌的毒力质粒，以及哥本哈根沙门氏菌和仙台沙门氏菌的隐蔽质粒属于同一不相容群，但都柏林沙门氏菌、鸡沙门氏菌、吉韦沙门氏菌、婴儿沙门氏菌和鸡白痢沙门氏菌的质粒不属于该不相容群。
Microb Pathog. 1990 Feb;8(2):101-7. doi: 10.1016/0882-4010(90)90074-z.