Kim Young Sik, Ahn Yoon-Ok, Lee Hyo Suk
Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea.
J Korean Med Sci. 2002 Apr;17(2):187-92. doi: 10.3346/jkms.2002.17.2.187.
To investigate risk factors for HCV infection according to the genotype, we studied 178 patients positive for HCV-PCR and 226 controls that were negative for the anti-HCV antibody. One hundred and twenty five controls (community control) were recruited from spouses of HCV-PCR-positive patients and the other 101 from hospital visitors (hospital control). HCV genotyping was performed by PCR, and epidemiological data were obtained from all participants. The distribution of HCV genotypes was as follows -- 1a (0.6%), 1b (39.9%), 2a (38.2%), 2b (0%), 3 (1.1%), and unclassified (20.2%). By multivariate analysis, blood transfusion (OR 2.90) and endoscopy (OR 2.80) were found to be risk factors for HCV genotype 1b versus the community control. Similarly, blood transfusion (OR 3.17) was found to be risk factors for HCV genotype 1b versus the hospital control. Blood transfusion (OR 2.75) and endoscopy (OR 3.57) were risk factors for HCV genotype 2a versus the community control, and blood transfusion (OR 4.55) and endoscopy (OR 2.16) were those versus the hospital control. Our results suggest that the risk factors for HCV infection are similar among the different genotypes. Blood transfusion and endoscopy were found to be associated with HCV infection.
为了根据基因型调查丙型肝炎病毒（HCV）感染的危险因素，我们研究了178例HCV-PCR阳性患者和226例抗-HCV抗体阴性的对照者。125名对照者（社区对照）从HCV-PCR阳性患者的配偶中招募，另外101名从医院访客中招募（医院对照）。通过PCR进行HCV基因分型，并从所有参与者中获取流行病学数据。HCV基因型的分布如下——1a（0.6%）、1b（39.9%）、2a（38.2%）、2b（0%）、3（1.1%）和未分类（20.2%）。通过多变量分析，发现输血（比值比[OR]2.90）和内镜检查（OR 2.80）是HCV 1b基因型相对于社区对照的危险因素。同样，输血（OR 3.17）是HCV 1b基因型相对于医院对照的危险因素。输血（OR 2.75）和内镜检查（OR 3.57）是HCV 2a基因型相对于社区对照的危险因素，输血（OR 4.55）和内镜检查（OR 2.16）是相对于医院对照的危险因素。我们的结果表明，不同基因型中HCV感染的危险因素相似。发现输血和内镜检查与HCV感染有关。
