Sharma S, Brown G C, Brown M M, Hollands H, Robins R, Shah G K
Cost-Effective Ocular Health Policy Unit, Department of Ophthalmology, Queen's University, Hotel Dieu Hospital, Kingston, ON, Canada.
Br J Ophthalmol. 2002 May;86(5):493-6. doi: 10.1136/bjo.86.5.493.
To assess the validity of the time trade-off (TTO) and standard reference gamble (SRG) techniques of utility assessment in patients with retinal disease. A cross section of eligible patients was studied and validity was determined through their relation with two logical constructs, visual acuity and scores from the Visual Function 14 (VF-14) index.
The study consisted of eligible patients presenting to a tertiary retinal facility who completed an interview. All patients had best corrected vision of 20/40 or worse in at least one eye. TTO and SRG utilities, as well as a VF-14 questionnaire, were administered through a standardised interview. Demographic and clinical (including Snellen visual acuity) information was also collected.
323 patients met these study criteria. Significant predictors of TTO utilities in the multivariate analysis were vision in the better seeing eye (p<0.01) and VF-14 scores (p<0.01). Significant predictors of standard gamble utilities were also vision in the better seeing eye (p<0.01) and VF-14 scores (p<0.05).
Both the standard gamble and TTO methods demonstrate strong validity when evaluated against visual acuity in the better seeing eye and the VF-14 score.
评估时间权衡法（TTO）和标准参考博弈法（SRG）在视网膜疾病患者效用评估中的有效性。对符合条件的患者进行横断面研究，并通过其与两个逻辑结构的关系来确定有效性，这两个逻辑结构为视力和视觉功能14（VF - 14）指数得分。
该研究包括到三级视网膜疾病治疗机构就诊并完成访谈的符合条件的患者。所有患者至少一只眼睛的最佳矫正视力为20/40或更差。通过标准化访谈来实施TTO和SRG效用评估，以及VF - 14问卷。还收集了人口统计学和临床（包括斯内伦视力）信息。
323名患者符合这些研究标准。多变量分析中，TTO效用的显著预测因素为视力较好眼睛的视力（p<0.01）和VF - 14得分（p<0.01）。标准博弈效用的显著预测因素也是视力较好眼睛的视力（p<0.01）和VF - 14得分（p<0.05）。
当对照视力较好眼睛的视力和VF - 14得分进行评估时，标准博弈法和TTO法均显示出很强的有效性。
