Sandberg-Wollheim M
Scand J Immunol. 1975;4(7):617-22. doi: 10.1111/j.1365-3083.1975.tb02669.x.
Cerebrospinal fluid (CSF) cells from six patients with meningoencephalitis of presumed viral origin were incubated in the presence of labeled amino acids. The cells of two of the patients synthesized IgG, IgA, and IgM (one patient) in vitro. The CSF of these two patients had an elevated level of IgG with oligoclonal distribution. The newly synthesized IgG also had an oligoclonal distribution. CSF cells of the other four patients were not shown to synthesize immunoglobulins in vitro. The CSF of these patients had a normal level of IgG with polyclonal distribution. The results demonstrate that in some patients with virus meningoencephalitis an immunoglobulin synthesis takes place locally and that at least part of the IgG shows a restricted heterogeneity. The results also suggest the presence of stimulated lymphocytes in the CSF of the same patients.
对6例推测为病毒源性脑膜脑炎患者的脑脊液（CSF）细胞进行标记氨基酸孵育。其中2例患者的细胞在体外合成了IgG、IgA和IgM（1例患者合成了所有三种免疫球蛋白）。这2例患者的脑脊液中IgG水平升高，呈寡克隆分布。新合成的IgG也呈寡克隆分布。另外4例患者的脑脊液细胞在体外未显示出合成免疫球蛋白。这些患者的脑脊液中IgG水平正常，呈多克隆分布。结果表明，在一些病毒性脑膜脑炎患者中，免疫球蛋白在局部合成，且至少部分IgG显示出有限的异质性。结果还提示这些患者的脑脊液中存在受刺激的淋巴细胞。
