Eibl M, Traugott U, Weippl G, Harasek G
Klin Wochenschr. 1978 Jul 1;56(13):655-8. doi: 10.1007/BF01477019.
Tetanus antitoxins were measured in serum and cerebro spinal fluid from 58 children--35 boys and 23 girls--with viral meningitis. The concentrations of IgG, IgA and IgM were also determined. The appearance of tetanus antitoxins in cerebral spinal fluid depends on absolute antitoxin levels in serum as well as on the antitoxin/IgG ratio. Antitoxin/IgG ratios in serum and cerebro spinal fluid were in the same order of magnitude. Detection of tetanus antitoxins in the cerebral spinal fluid of children with viral meningitis shows clearly that antibody found in cerebral spinal fluid is not an absolute proof of a certain disease. The results further indicate that local production of IgG antibody cannot be postulated by detecting certain antibodies in the CSF. It is also necessary to prove that antibody/globulin ratios are of significantly different magnitude in serum and CFS.
对58名患有病毒性脑膜炎的儿童（35名男孩和23名女孩）的血清和脑脊液进行了破伤风抗毒素检测。同时还测定了IgG、IgA和IgM的浓度。脑脊液中破伤风抗毒素的出现取决于血清中的绝对抗毒素水平以及抗毒素与IgG的比例。血清和脑脊液中的抗毒素与IgG比例处于相同的数量级。在患有病毒性脑膜炎的儿童脑脊液中检测到破伤风抗毒素清楚地表明，在脑脊液中发现的抗体并非某种特定疾病的绝对证据。结果还表明，不能通过检测脑脊液中的某些抗体来假定IgG抗体的局部产生。还必须证明血清和脑脊液中的抗体与球蛋白比例有显著不同。
