类风湿关节炎与绝经后骨质疏松症的骨代谢比较。
Bone metabolism in rheumatoid arthritis compared with postmenopausal osteoporosis.
作者信息
van Soesbergen R M, Lips P, van den Ende A, van der Korst J K
出版信息
Ann Rheum Dis. 1986 Feb;45(2):149-55. doi: 10.1136/ard.45.2.149.
Abstract
Calcium and bone metabolism in 29 rheumatoid arthritis (RA) patients were compared with those in 27 postmenopausal osteoporotic patients. Signs of vitamin D deficiency were found in 20 RA patients, including 12 who took recommended amounts of vitamin D in their diets and were exposed to sufficient sunlight, and in none of the osteoporotic patients. There were no signs of malabsorption. In six out of 15 patients we found increased liver enzyme activity, which may have a role in vitamin D metabolism. We propose the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on vitamin D metabolism in the liver as a possible explanation.
摘要
对29例类风湿性关节炎（RA）患者和27例绝经后骨质疏松症患者的钙和骨代谢情况进行了比较。在20例RA患者中发现了维生素D缺乏的迹象，其中包括12例在饮食中摄入了推荐量的维生素D且接受了充足阳光照射的患者，而骨质疏松症患者中未发现维生素D缺乏迹象。没有吸收不良的迹象。在15例患者中有6例发现肝酶活性增加，这可能在维生素D代谢中起作用。我们提出非甾体抗炎药（NSAIDs）对肝脏中维生素D代谢的影响是一种可能的解释。
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