Bassin Sarice, Smith Teresa L, Bleck Thomas P
Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Crit Care. 2002 Apr;6(2):137-42. doi: 10.1186/cc1472. Epub 2002 Mar 15.
Status epilepticus (SE) has an annual incidence exceeding 100,000 cases in the United States alone, of which more than 20% result in death. Thus, increased awareness of presentation, etiologies, and treatment of SE is essential in the practice of critical care medicine. This review discusses current definitions of SE, as well as its clinical presentation and classification. The recent literature on epidemiology is reviewed, including morbidity and mortality data. An overview of the systemic pathophysiologic effects of SE is presented. Finally, significant studies on the treatment of acute SE and refractory SE are reviewed, including the use of anticonvulsants, such as benzodiazepines, and other drugs.
仅在美国，癫痫持续状态（SE）的年发病率就超过10万例，其中超过20%会导致死亡。因此，提高对SE的表现、病因和治疗的认识对于重症医学实践至关重要。本综述讨论了SE的当前定义及其临床表现和分类。回顾了近期关于流行病学的文献，包括发病率和死亡率数据。介绍了SE的全身病理生理效应概述。最后，回顾了关于急性SE和难治性SE治疗的重要研究，包括抗惊厥药物（如苯二氮䓬类药物）和其他药物的使用。
