性别与单（双链）断裂
Sex and the single (double-strand) break.
作者信息
Martini Emmanuelle, Keeney Scott
机构信息
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
出版信息
Mol Cell. 2002 Apr;9(4):700-2. doi: 10.1016/s1097-2765(02)00512-9.
Abstract
It has been known for some time that DNA double-strand breaks (DSBs) initiate homologous recombination during meiosis. Two recent studies show that the fate of a single DSB in yeast is strongly influenced by the presence of other breaks in the genome, hinting that cell-wide or chromosome-regional mechanisms control the outcome of DSB repair.
摘要
一段时间以来，人们已经知道DNA双链断裂（DSB）在减数分裂过程中引发同源重组。最近的两项研究表明，酵母中单个DSB的命运受到基因组中其他断裂存在的强烈影响，这暗示全细胞或染色体区域机制控制着DSB修复的结果。
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