• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

性别与单（双链）断裂

Sex and the single (double-strand) break.

作者信息

Martini Emmanuelle, Keeney Scott

机构信息

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

出版信息

Mol Cell. 2002 Apr;9(4):700-2. doi: 10.1016/s1097-2765(02)00512-9.

DOI:10.1016/s1097-2765(02)00512-9
PMID:11983162
Abstract

It has been known for some time that DNA double-strand breaks (DSBs) initiate homologous recombination during meiosis. Two recent studies show that the fate of a single DSB in yeast is strongly influenced by the presence of other breaks in the genome, hinting that cell-wide or chromosome-regional mechanisms control the outcome of DSB repair.

摘要

一段时间以来，人们已经知道DNA双链断裂（DSB）在减数分裂过程中引发同源重组。最近的两项研究表明，酵母中单个DSB的命运受到基因组中其他断裂存在的强烈影响，这暗示全细胞或染色体区域机制控制着DSB修复的结果。

相似文献

1
Sex and the single (double-strand) break.性别与单（双链）断裂
Mol Cell. 2002 Apr;9(4):700-2. doi: 10.1016/s1097-2765(02)00512-9.
2
Wild-type levels of Spo11-induced DSBs are required for normal single-strand resection during meiosis.减数分裂过程中正常的单链切除需要Spo11诱导的双链断裂达到野生型水平。
Mol Cell. 2002 Apr;9(4):835-46. doi: 10.1016/s1097-2765(02)00498-7.
3
Switching yeast from meiosis to mitosis: double-strand break repair, recombination and synaptonemal complex.酵母从减数分裂转换为有丝分裂：双链断裂修复、重组与联会复合体
Genes Cells. 1997 Aug;2(8):487-98. doi: 10.1046/j.1365-2443.1997.1370335.x.
4
Homologous chromosome associations and nuclear order in meiotic and mitotically dividing cells of budding yeast.芽殖酵母减数分裂和有丝分裂细胞中的同源染色体联会及核秩序
Adv Genet. 2002;46:49-90. doi: 10.1016/s0065-2660(02)46004-x.
5
Sex and the single cell: meiosis in yeast.性别与单细胞：酵母中的减数分裂
Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10450-6. doi: 10.1073/pnas.92.23.10450.
6
The control of Spo11's interaction with meiotic recombination hotspots.Spo11与减数分裂重组热点相互作用的调控。
Genes Dev. 2005 Jan 15;19(2):255-69. doi: 10.1101/gad.321105.
7
Interactions between Mei4, Rec114, and other proteins required for meiotic DNA double-strand break formation in Saccharomyces cerevisiae.酿酒酵母中减数分裂DNA双链断裂形成所需的Mei4、Rec114与其他蛋白质之间的相互作用。
Chromosoma. 2007 Oct;116(5):471-86. doi: 10.1007/s00412-007-0111-y. Epub 2007 Jun 9.
8
DNA motif associated with meiotic double-strand break regions in Saccharomyces cerevisiae.与酿酒酵母减数分裂双链断裂区域相关的DNA基序。
EMBO Rep. 2000 Sep;1(3):232-8. doi: 10.1093/embo-reports/kvd047.
9
Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.Mre11 和 Exo1 有助于在不依赖 Spo11 的情况下形成的减数分裂双链断裂处起始和进行修复。
DNA Repair (Amst). 2011 Feb 7;10(2):138-48. doi: 10.1016/j.dnarep.2010.11.008. Epub 2010 Dec 13.
10
Association of Mre11p with double-strand break sites during yeast meiosis.酵母减数分裂过程中Mre11p与双链断裂位点的关联。
Mol Cell. 2004 Feb 13;13(3):389-401. doi: 10.1016/s1097-2765(04)00034-6.

引用本文的文献

1
RRM1 promotes homologous recombination and radio/chemo-sensitivity via enhancing USP11 and E2F1-mediated RAD51AP1 transcription.核糖核苷酸还原酶M1亚基（RRM1）通过增强泛素特异性蛋白酶11（USP11）和E2F1介导的RAD51相关蛋白1（RAD51AP1）转录来促进同源重组以及放射/化学敏感性。
Cell Death Discov. 2024 Dec 18;10(1):496. doi: 10.1038/s41420-024-02267-x.
2
Omics data reveal the unusual asexual-fruiting nature and secondary metabolic potentials of the medicinal fungus Cordyceps cicadae.组学数据揭示了药用真菌蝉花不寻常的无性产果特性和次生代谢潜力。
BMC Genomics. 2017 Aug 30;18(1):668. doi: 10.1186/s12864-017-4060-4.
3
Global phylogenomic analysis disentangles the complex evolutionary history of DNA replication in archaea.
全球系统基因组学分析揭示了古菌 DNA 复制的复杂进化历史。
Genome Biol Evol. 2014 Jan;6(1):192-212. doi: 10.1093/gbe/evu004.
4
Modulation of the transcription regulatory program in yeast cells committed to sporulation.对致力于孢子形成的酵母细胞中转录调控程序的调节。
Genome Biol. 2006;7(3):R20. doi: 10.1186/gb-2006-7-3-r20. Epub 2006 Mar 8.
5
Mcp7, a meiosis-specific coiled-coil protein of fission yeast, associates with Meu13 and is required for meiotic recombination.Mcp7是裂殖酵母中一种减数分裂特异性的卷曲螺旋蛋白，它与Meu13相互作用，是减数分裂重组所必需的。
Nucleic Acids Res. 2004 Jun 21;32(11):3325-39. doi: 10.1093/nar/gkh654. Print 2004.
6
The signal from the initiation of meiotic recombination to the first division of meiosis.从减数分裂重组起始到减数第一次分裂的信号。
Eukaryot Cell. 2004 Jun;3(3):598-609. doi: 10.1128/EC.3.3.598-609.2004.
7
Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae.酿酒酵母中宿主因子对转座子诱导的DNA发夹的微同源性依赖性末端连接和修复
Mol Cell Biol. 2004 Feb;24(3):1351-64. doi: 10.1128/MCB.24.3.1351-1364.2004.
8
Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p.对减数分裂重组起始复合物的支持：Rec102p、Rec104p和Spo11p之间的相互作用
Mol Cell Biol. 2003 Aug;23(16):5928-38. doi: 10.1128/MCB.23.16.5928-5938.2003.
9
Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution.拓扑异构酶VI - B亚基的结构：对II型拓扑异构酶机制及进化的启示
EMBO J. 2003 Jan 2;22(1):151-63. doi: 10.1093/emboj/cdg008.