Krabbe K S, Bruunsgaard H, Qvist J, Fonsmark L, Møller K, Hansen C M, Skinhøj P, Pedersen B K
Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Clin Diagn Lab Immunol. 2002 May;9(3):731-5. doi: 10.1128/cdli.9.3.731-735.2002.
Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.
17名志愿者接受了静脉注射内毒素（2纳克/千克体重）。内毒素诱导的淋巴细胞减少主要由具有未成熟表型（CD45RA(+) CD45RO(-)）的细胞组成，这些细胞不太可能发生凋亡（CD28(+)），而消失率最高的细胞则具有活化表型（CD45RA(-) CD45RO(+)）以及与凋亡相关的表型（CD95(+) CD28(-)）。总之，内毒素诱导的淋巴细胞减少反映了易于发生凋亡的活化淋巴细胞从循环中消失。
