Hemminki Kari, Li X
Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden.
Br J Cancer. 2002 May 6;86(9):1414-8. doi: 10.1038/sj.bjc.6600227.
We used the nation-wide Swedish Family-Cancer Database to analyse the risk of nervous system tumours, leukaemia and non-Hodgkin's lymphoma in age groups 0-4 and 0-19 years among Swedish-born offspring of immigrants. The study included 850 000 individuals with an immigrant background, including European, Asian and American parents. We calculated standardised incidence ratios for the above three malignancies using Swedish offspring as a reference. Subjects were grouped by region or by selected countries of parental origin. No group differed significantly from Swedes in the occurrence of nervous system neoplasm or leukaemia. Offspring of Yugoslav fathers (SIR 2.27) and Turkish parents were at increased risk of non-Hodgkin's lymphoma. The highest risk was noted for non-Hodgkin's lymphoma among young offspring (0-4 years) of two Turkish parents (6.87). The currently available limited data on rates for childhood non-Hodgkin's lymphoma in these countries do not explain the risk in the offspring of immigrants. Yugoslavs and Turks are recent immigrant groups to Sweden, and their offspring have been subject to much population mixing, perhaps leading to recurring infections and immunological stimulation, which may contribute to their excess of lymphomas.
我们使用瑞典全国家庭癌症数据库，分析了移民的瑞典裔后代中0至4岁和0至19岁年龄组患神经系统肿瘤、白血病和非霍奇金淋巴瘤的风险。该研究纳入了85万名有移民背景的个体，其父母包括欧洲、亚洲和美洲人。我们以瑞典后代作为参照，计算了上述三种恶性肿瘤的标准化发病率。研究对象按地区或按父母原籍国进行分组。在神经系统肿瘤或白血病的发病情况方面，没有哪个组与瑞典人有显著差异。南斯拉夫父亲的后代（标准化发病率为2.27）以及父母为土耳其人的后代患非霍奇金淋巴瘤的风险增加。父母均为土耳其人的年幼后代（0至4岁）患非霍奇金淋巴瘤的风险最高（6.87）。目前这些国家关于儿童非霍奇金淋巴瘤发病率的有限数据无法解释移民后代中的这种风险。南斯拉夫人和土耳其人是近期移民到瑞典的群体，他们的后代经历了大量的人口融合，这可能导致反复感染和免疫刺激，进而可能导致他们淋巴瘤发病率偏高。
