感染或未感染幽门螺杆菌的患者的ABO、Lewis血型分泌型和非分泌型表型
ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus.
作者信息
de Mattos Luiz Carlos, Rodrigues Cintra Juliana, Sanches Fábio Eduardo, Alves da Silva Rita de Cássia Martins, Ruiz Milton Artur, Moreira Haroldo Wilson
机构信息
Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto, Brazil.
出版信息
Sao Paulo Med J. 2002 Mar 7;120(2):55-8. doi: 10.1590/s1516-31802002000200006.
CONTEXT
Epidemiological studies have demonstrated higher frequencies of the O blood group and the non-secretor phenotype of ABH antigens among patients suffering from peptic ulcers. Since Helicobacter pylori has been established as the main etiological factor in this disease, controversies about the associations of the ABO and Lewis blood group phenotypes and secretor and non-secretor phenotypes in relation to susceptibility towards infection by this bacillus have been presented.
OBJECTIVE
To verify the frequencies of ABO, Lewis blood group phenotypes, secretor and non-secretor phenotypes in patients infected or uninfected by H. pylori.
DESIGN
Cross-sectional study.
SETTING
Outpatient clinic.
PARTICIPANTS
One hundred and twenty patients with dyspeptic symptoms who underwent endoscopy.
MAIN MEASUREMENTS
ABO and Lewis blood group phenotypes were determined by a standard hemagglutination test and the secretor and non-secretor phenotypes were evaluated by saliva samples using the inhibitor hemagglutination test.
RESULTS
The diagnosis of infection, made via breath and urea tests and confirmed using polymerase chain reaction (PCR) in gastric biopsy fragments, showed the presence of H. pylori in 61.7% of the patients and absence in 38.3%. The differences between the frequencies of the ABO blood group phenotypes among infected (A 27.0%; B 12.2%; AB 4.0% and O 56.8%) and uninfected patients (A 58.7%; B 13.0%; AB 4.3% and O 24.0%) were significant. The Lewis blood type, secretor and non-secretor phenotypes showed homogeneous distribution between the groups of patients analyzed.
CONCLUSIONS
Our results suggest that the infection of H. pylori can be related to ABO blood groups but not to the Lewis blood group nor to secretor and non-secretor phenotypes.
背景
流行病学研究表明，消化性溃疡患者中O血型以及ABH抗原的非分泌型表型出现频率更高。由于幽门螺杆菌已被确认为该病的主要病因，因此出现了关于ABO和Lewis血型表型以及分泌型和非分泌型表型与该杆菌感染易感性之间关联的争议。
目的
验证幽门螺杆菌感染或未感染患者中ABO、Lewis血型表型、分泌型和非分泌型表型的频率。
设计
横断面研究。
地点
门诊诊所。
参与者
120例有消化不良症状且接受了内镜检查的患者。
主要测量指标
ABO和Lewis血型表型通过标准血凝试验确定，分泌型和非分泌型表型通过使用抑制血凝试验的唾液样本进行评估。
结果
通过呼气试验和尿素试验诊断感染，并在胃活检组织碎片中使用聚合酶链反应（PCR）进行确认，结果显示61.7%的患者存在幽门螺杆菌，38.3%的患者不存在。感染患者（A 27.0%；B 12.2%；AB 4.0%；O 56.8%）和未感染患者（A 58.7%；B 13.0%；AB 4.3%；O 24.0%）之间ABO血型表型频率差异显著。Lewis血型、分泌型和非分泌型表型在分析的患者组之间显示出均匀分布。
结论
我们的结果表明，幽门螺杆菌感染可能与ABO血型有关，但与Lewis血型以及分泌型和非分泌型表型无关。
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