Lewis和ABO血型抗原在幽门螺杆菌感染中的作用
Role of the Lewis and ABO Blood Group Antigens in Helicobacter pylori Infection.
作者信息
Keramati Mohammad Reza, Sadeghian Mohammad Hadi, Ayatollahi Hosein, Badiee Zahra, Shakibayi Hosein, Moghimi-Roudi Ali
机构信息
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, P.O Box 9137913316, Mashhad, Iran.
出版信息
Malays J Med Sci. 2012 Jul;19(3):17-21.
BACKGROUND
Helicobacter pylori infection is a major risk factor for chronic gastritis and gastric cancer. Some findings show increased frequencies of these diseases in individuals with type O blood and in secretors (expressing Le(b) antigen), but other studies have not found any relationship between blood groups and this infection. Given that H. pylori infection and gastric cancer are common in Iran, the assessment of the pathogenesis of this infection in relation to these blood groups could be valuable.
METHODS
In a cross-sectional study, we determined the ABO and Lewis blood groups of participants using the tube method and evaluated the level of anti-H. pylori immunoglobulin G using an enzyme-linked immunosorbent assay. This study included 171 Iranian blood donors from Mashhad, Iran, during 2010. The significance of the differences in the frequencies of the Lewis and ABO phenotypes between individuals infected with and without H. Pylori infection were tested using the Chi-square test. A P-value < 0.05 was considered significant.
RESULTS
H. pylori infection was found in 76.6% of the study subjects (n = 131). The most common ABO blood group was O (33.9%), and the most common Lewis blood group was Le(a-b+) (54.7%). The frequencies of the ABO, Lewis, and secretion phenotypes were not significantly different between the infected and uninfected subjects.
CONCLUSION
We did not find any significant relationship between the Lewis, ABO, and secretion phenotypes and H. pylori infection.
背景
幽门螺杆菌感染是慢性胃炎和胃癌的主要危险因素。一些研究结果显示，O型血个体和分泌者（表达Le(b)抗原）中这些疾病的发病率增加，但其他研究未发现血型与这种感染之间存在任何关联。鉴于幽门螺杆菌感染和胃癌在伊朗很常见，评估这种感染与这些血型相关的发病机制可能具有重要价值。
方法
在一项横断面研究中，我们采用试管法确定参与者的ABO和Lewis血型，并使用酶联免疫吸附测定法评估抗幽门螺杆菌免疫球蛋白G的水平。本研究纳入了2010年期间来自伊朗马什哈德的171名伊朗献血者。使用卡方检验来检验幽门螺杆菌感染组和未感染组之间Lewis和ABO表型频率差异的显著性。P值<0.05被认为具有显著性。
结果
在76.6%（n = 131）的研究对象中发现了幽门螺杆菌感染。最常见的ABO血型是O型（33.9%），最常见的Lewis血型是Le(a-b+)（54.7%）。感染组和未感染组之间ABO、Lewis和分泌型表型的频率没有显著差异。
结论
我们未发现Lewis、ABO和分泌型表型与幽门螺杆菌感染之间存在任何显著关联。
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