Aryana Kamran, Keramati Mohammad Reza, Zakavi Seyed Rasoul, Sadeghian Mohammad Hadi, Akbari Hedieh
Department of Nuclear Medicine, Nuclear Medicine Research Center, Mashhad, Iran ; Department of Hematopathology, Mashhad University of Medical Sciences, Mashhad, Iran.
Niger Med J. 2013 May;54(3):196-9. doi: 10.4103/0300-1652.114583.
Helicobacter pylori infection is a basic risk factor for chronic gastritis, and gastric carcinoma. Based on some studies, the reason is binding of H. pylori to H and Le(b) antigens in gastric mucosa. However, some other findings have not determined any association between the infection and these antigens. Because of this controversy and the fact that H. pylori infection and gastric adenocarcinoma are common diseases in Iran, the assessment of the association of H. pylori infection with these blood groups could be valuable.
In a cross sectional study on 135 adult dyspeptic patients in Mashhad, Iran, from 2009 to 2010, H. pylori infection was evaluated by using the Heliprobe (14)C-urea breath test and the ABO and Lewis blood group antigens were determined by the tube method. Association between the Lewis and ABO phenotypes with H. pylori infection were analysed by Fisher's exact test. A P ≤ 0.05 was considered to be significant.
68 (50.4%) patients were positive for H. pylori infection. The frequencies of the ABO, Lewis and secretion phenotypes were not significant in the infected and non-infected patients. We also did not find a significant association between Le(a) and Le(b) antigens and this infection.
We could not establish a significant association between the Lewis, ABO and secretion phenotypes with H. pylori infection. Diversity of sequences of blood group antigen b-binding adhesion (babA gene) of H. pylori may be a reason why our findings are different from other studies in other geographic areas.
幽门螺杆菌感染是慢性胃炎和胃癌的一个基本危险因素。基于一些研究，原因是幽门螺杆菌与胃黏膜中的H和Le(b)抗原结合。然而，其他一些研究结果并未确定这种感染与这些抗原之间存在任何关联。鉴于这一争议以及幽门螺杆菌感染和胃腺癌在伊朗是常见疾病这一事实，评估幽门螺杆菌感染与这些血型之间的关联可能具有重要意义。
在2009年至2010年对伊朗马什哈德的135名成年消化不良患者进行的一项横断面研究中，使用Heliprobe (14)C尿素呼气试验评估幽门螺杆菌感染情况，并通过试管法测定ABO和Lewis血型抗原。采用Fisher精确检验分析Lewis和ABO表型与幽门螺杆菌感染之间的关联。P≤0.05被认为具有统计学意义。
68例（50.4%）患者幽门螺杆菌感染呈阳性。ABO、Lewis和分泌型表型在感染和未感染患者中的频率无显著差异。我们也未发现Le(a)和Le(b)抗原与这种感染之间存在显著关联。
我们未能确定Lewis、ABO和分泌型表型与幽门螺杆菌感染之间存在显著关联。幽门螺杆菌血型抗原b结合黏附素（babA基因）序列的多样性可能是我们的研究结果与其他地理区域的其他研究不同的原因。
