Livermore David M, James Dorothy, Reacher Mark, Graham Catriona, Nichols Thomas, Stephens Peter, Johnson Alan P, George Robert C
Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, UK.
Emerg Infect Dis. 2002 May;8(5):473-8. doi: 10.3201/eid0805.010204.
The Public Health Laboratory Service receives antibiotic susceptibility data for bacteria from bloodstream infections from most hospitals in England and Wales. These data were used to ascertain resistance trends to ciprofloxacin from 1990 through 1999 for the most prevalent gram-negative agents: Escherichia coli, Klebsiella spp., Enterobacter spp., and Proteus mirabilis. Significant increases in resistance were observed for all four species groups. For E. coli, ciprofloxacin resistance rose from 0.8% in 1990 to 3.7% in 1999 and became widely scattered among reporting hospitals. The prevalence of resistance in Klebsiella spp. rose from 3.5% in 1990, to 9.5% in 1996 and 7.1% in 1999, while that in Enterobacter spp. rose from 2.1% in 1990 to 10.5% in 1996 and 10.9% in 1999. For both Klebsiella and Enterobacter spp., most resistance was localized in a few centers. Resistance was infrequent and scattered in P. mirabilis, but reached a prevalence of 3.3% in 1999.
公共卫生实验室服务机构从英格兰和威尔士的大多数医院收集了血液感染细菌的抗生素敏感性数据。这些数据用于确定1990年至1999年期间最常见的革兰氏阴性菌对环丙沙星的耐药趋势，这些细菌包括大肠杆菌、克雷伯菌属、肠杆菌属和奇异变形杆菌。在所有四个菌种组中均观察到耐药性显著增加。对于大肠杆菌，环丙沙星耐药率从1990年的0.8%升至1999年的3.7%，且在各报告医院中广泛分布。克雷伯菌属的耐药率从1990年的3.5%升至1996年的9.5%和1999年的7.1%，而肠杆菌属的耐药率则从1990年的2.1%升至1996年的10.5%和1999年的10.9%。对于克雷伯菌属和肠杆菌属，大多数耐药情况集中在少数几个中心。奇异变形杆菌的耐药情况不常见且分布分散，但在1999年其耐药率达到了3.3%。
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