West J V
Children's Services, Leicestershire and Rutland Healthcare Trust, Leicester, UK.
Br Med Bull. 2002;61(1):215-30. doi: 10.1093/bmb/61.1.215.
Upper respiratory tract infections are common and important. Although rarely fatal, they are a source of significant morbidity and carry a considerable economic burden. Numerous therapies for the common cold have no effect on symptoms or outcome. Complications such as cough are not improved by over-the-counter preparations, while labelling cough alone as a symptom of asthma may result in unnecessary use of inhaled steroid treatment. Clinical presentation of sore throat does not accurately predict whether the infection is viral or bacterial, while throat culture and rapid antigen tests do not significantly change prescribing practice. Antibiotics have only a limited place in the management of recurrent sore throat due to group A beta-haemolytic streptococcal infection. Routine use of antibiotics in upper respiratory infection enhances parent belief in their effectiveness and increases the likelihood of future consultation in primary care for minor self-limiting illness. Respiratory viruses play a major role in the aetiology of acute otitis media (AOM); prevention includes the use of influenza or RSV vaccination, in addition to reducing other risk factors such as early exposure to respiratory viruses in day-care settings and to environmental tobacco smoke. The use of ventilation tubes (grommets) in secretory otitis media (SOM) remains controversial with conflicting data on developmental outcome and quality of life in young children. New conjugate pneumococcal vaccines appear safe in young children and prevent 6-7% of clinically diagnosed AOM.
上呼吸道感染很常见且很重要。虽然很少致命,但它们是导致显著发病率的一个原因,并带来相当大的经济负担。许多治疗普通感冒的方法对症状或预后没有效果。非处方制剂并不能改善诸如咳嗽等并发症,而仅将咳嗽标记为哮喘症状可能会导致不必要地使用吸入性类固醇治疗。咽痛的临床表现并不能准确预测感染是病毒性还是细菌性的,而咽喉培养和快速抗原检测并不会显著改变处方习惯。对于由A组β溶血性链球菌感染引起的复发性咽痛,抗生素在治疗中作用有限。在上呼吸道感染中常规使用抗生素会增强患者对其有效性的信心,并增加未来因轻微自限性疾病在初级保健机构就诊的可能性。呼吸道病毒在急性中耳炎(AOM)的病因中起主要作用;预防措施包括使用流感疫苗或呼吸道合胞病毒(RSV)疫苗,此外还要减少其他风险因素,如在日托场所过早接触呼吸道病毒以及接触环境烟草烟雾。在分泌性中耳炎(SOM)中使用通气管(鼓膜切开置管)仍然存在争议,关于幼儿发育结局和生活质量的数据相互矛盾。新型结合肺炎球菌疫苗在幼儿中似乎是安全的,可预防6% - 7%临床诊断的AOM。