[两岁幼儿的家庭环境与急性丙二醇中毒。一则罕见病例报告]
[Home environment and acute propylene glycol intoxication in a two-year old. An unusual case report].
作者信息
Guillot M, Bocquet G, Eckart P, Amiour M, el-Hachem C, Garnier R, Galliot-Guilley M, Haguenoer J M
机构信息
Service de pédiatrie, CHG Robert-Bisson, BP 97223, 14107 Lisieux, France.
出版信息
Arch Pediatr. 2002 Apr;9(4):382-4. doi: 10.1016/s0929-693x(01)00797-7.
BACKGROUND
Acute propylene glycol intoxication in a two-year-old toddler underlines the potentially serious toxicity in children of this chemical agent present as a diluent in many drugs and environmental products such as cosmetics, diapers, cleansing towels, despite a common consideration of safety and lack of toxicity.
CASE REPORT
A two-years-old boy previously healthy was found in the morning by his parents in his cradle, lethargic, responsive only to sharp pain. On admission, vital signs were: temperature 38.5 degrees C, lethargy, polypnea; propylene glycol intoxication through disposable cleansing towels chewing was ascertained by anamnesis and blood urine analyses which revealed metabolic acidosis and serum propylene glycol peak.
CONCLUSION
Environmental acute propylene glycol intoxication must be considered and searched for in front of a metabolic acidosis case of unknown origin in children.
背景
一名两岁幼儿急性丙二醇中毒事件突显了这种化学物质对儿童潜在的严重毒性。丙二醇作为稀释剂存在于许多药物以及化妆品、尿布、清洁毛巾等环保产品中，尽管人们通常认为它安全无毒。
病例报告
一名此前健康的两岁男孩早晨被父母发现躺在摇篮里，昏昏欲睡，仅对剧痛有反应。入院时，生命体征如下：体温38.5摄氏度，嗜睡，呼吸急促；通过问诊和血尿分析确诊因咀嚼一次性清洁毛巾导致丙二醇中毒，结果显示存在代谢性酸中毒且血清丙二醇达到峰值。
结论
对于病因不明的儿童代谢性酸中毒病例，必须考虑并排查环境性急性丙二醇中毒情况。
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