Claus Melissa A, Jandrey Karl E, Poppenga Robert H
Veterinary Medical Teaching Hospital, University of California Davis, Davis, CA 95616, USA.
J Vet Emerg Crit Care (San Antonio). 2011 Dec;21(6):679-83. doi: 10.1111/j.1476-4431.2011.00688.x.
To describe the clinical course, treatment, and outcome of a dog with propylene glycol intoxication.
An adult castrated male Australian cattle dog presented to an emergency clinic for an acute onset of ataxia and disorientation after roaming a construction site unsupervised. He tested positive for ethylene glycol using a point-of-care test kit. Treatment for ethylene glycol intoxication included intermittent intravenous boluses of 20% ethanol and hemodialysis. Predialysis and postdialysis blood samples were submitted to the toxicology lab to assess for both ethylene and propylene glycol. The patient tested negative for ethylene glycol and positive for propylene glycol at 1100 mg/dL predialysis and 23 mg/dL postdialysis. The dog made a full recovery.
To the authors' knowledge, this is the first report of documented propylene glycol intoxication in a dog, as well as the first report to describe hemodialysis as treatment for propylene glycol intoxication in a dog.
描述一只丙二醇中毒犬的临床病程、治疗及预后情况。
一只成年去势雄性澳大利亚牧牛犬在无人监管下游荡建筑工地后,因急性共济失调和定向障碍被送至一家急诊诊所。使用即时检验试剂盒检测,其乙二醇检测呈阳性。乙二醇中毒的治疗包括间歇性静脉推注20%乙醇和血液透析。透析前和透析后的血样被送至毒理学实验室,以评估乙二醇和丙二醇。透析前患者丙二醇检测呈阳性,浓度为1100mg/dL,透析后为23mg/dL,乙二醇检测呈阴性。该犬完全康复。
据作者所知,这是犬丙二醇中毒的首次文献报道,也是首次描述血液透析作为犬丙二醇中毒治疗方法的报道。