Parker Mark G, Fraser Gilles L, Watson Donald M, Riker Richard R
Division of Nephrology and Renal Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, Maine 04102, USA.
Intensive Care Med. 2002 Jan;28(1):81-4. doi: 10.1007/s00134-001-1125-1. Epub 2001 Nov 13.
We report a case of successful treatment of propylene glycol toxicity by discontinuation of propylene glycol administration and hemodialysis therapy. A critically ill woman receiving high dose intravenous lorazepam therapy is described. Although propylene glycol toxicity often resolves promptly after discontinuation of the causative parenteral source, renal or liver dysfunction may prolong the sequelae of propylene glycol infusion. Hemodialysis efficiently lowers propylene glycol serum concentrations in a manner analogous to extracorporeal therapy for other small molecular weight alcohol intoxications. Therefore, hemodialysis may be a useful component of therapy for critically ill patients exhibiting propylene glycol toxicity in the context of multiple organ dysfunction.
我们报告了一例通过停止丙二醇给药及血液透析治疗成功治愈丙二醇中毒的病例。本文描述了一名接受大剂量静脉注射劳拉西泮治疗的重症女性患者。尽管丙二醇中毒通常在停止使用致病的肠外来源后迅速缓解，但肾功能或肝功能障碍可能会延长丙二醇输注的后遗症。血液透析能有效地降低丙二醇血清浓度，其方式类似于对其他小分子醇类中毒的体外治疗。因此，对于在多器官功能障碍背景下出现丙二醇中毒的重症患者，血液透析可能是治疗的一个有用组成部分。
