Allampallam Krishnan, Shetty Vilasini, Mundle Suneel, Dutt Diya, Kravitz Howard, Reddy Poluru L, Alvi Sairah, Galili Naomi, Saberwal Gurveen S, Anthwal Shalini, Shaikh Maliha W, York Aaron, Raza Azra
Rush Cancer Institute, Rush-Presbyterian-St Luke's Medical Center, Chicago, Illinois 60612, USA.
Int J Hematol. 2002 Apr;75(3):289-97. doi: 10.1007/BF02982044.
Labeling index (LI), apoptosis, levels of 2 pro-apoptotic cytokines tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta(TGF-beta), and the number of monocyte/macrophage cells that are the likely source of the cytokines were simultaneously measured in plastic-embedded bone marrow (BM) biopsy sections of 145 patients with myelodysplastic syndromes (MDS). TNF-alpha was correlated with TGF-beta (P = .001) and with monocyte/macrophage cells (P = .003). Patients with excess blasts in their marrows had a higher TGF-beta level (P = .01) and monocyte/macrophage number (P = .05). In a linear regression model,TGF-beta emerged as the most significant biological difference between patients who have excess of blasts and those who do not (P = .01). We conclude that in addition to TNF-alpha, TGF-beta also plays a significant role in the initiation and pathogenesis of MDS, and that a more precise definition of its role will likely identify better preventive and therapeutic strategies.
在145例骨髓增生异常综合征（MDS）患者的塑料包埋骨髓（BM）活检切片中，同时检测了标记指数（LI）、细胞凋亡、两种促凋亡细胞因子肿瘤坏死因子-α（TNF-α）和转化生长因子-β（TGF-β）的水平，以及可能是细胞因子来源的单核细胞/巨噬细胞数量。TNF-α与TGF-β相关（P = 0.001），与单核细胞/巨噬细胞相关（P = 0.003）。骨髓中原始细胞过多的患者TGF-β水平较高（P = 0.01），单核细胞/巨噬细胞数量较多（P = 0.05）。在一个线性回归模型中，TGF-β是骨髓原始细胞过多和不过多患者之间最显著的生物学差异（P = 0.01）。我们得出结论，除了TNF-α外，TGF-β在MDS的起始和发病机制中也起重要作用，对其作用的更精确界定可能会确定更好的预防和治疗策略。
