Budavari Adriane I, Whitaker Michael D, Helmers Richard A
Division of Community Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Mayo Clin Proc. 2002 May;77(5):495-9. doi: 10.4065/77.5.495.
Graves disease is an autoimmune thyroid condition characterized by the production of autoantibodies against the thyrotropin receptor. The autoantibodies mimic the effect of the hormone on thyroid cells, which stimulates autonomous production of thyroxine and triiodothyronine. It has been hypothesized that cross-reactivity of autoantibodies may result in Graves ophthalmopathy and dermopathy. A seldom-recognized feature of Graves disease is thymic hyperplasia. We report 2 patients with Graves disease and incidentally discovered anterior mediastinal masses presumed to be thymic hyperplasia. In both cases, these masses regressed spontaneously after treatment of hyperthyroidism.
格雷夫斯病是一种自身免疫性甲状腺疾病，其特征是产生针对促甲状腺激素受体的自身抗体。这些自身抗体模拟了激素对甲状腺细胞的作用，刺激甲状腺自主产生甲状腺素和三碘甲状腺原氨酸。据推测，自身抗体的交叉反应性可能导致格雷夫斯眼病和皮肤病。格雷夫斯病一个很少被认识到的特征是胸腺增生。我们报告了2例格雷夫斯病患者，他们偶然发现前纵隔肿块，推测为胸腺增生。在这两个病例中，这些肿块在甲状腺功能亢进症治疗后自发消退。
