感染性和非感染性原因导致的横纹肌溶解症。

Rhabdomyolysis of infectious and noninfectious causes.

作者信息

Blanco José Ramón, Zabalza Marta, Salcedo Javier, Echeverria Lorenzo, García Ana, Vallejo Manuel

机构信息

Servicio de Medicina Interna y Documentación Clínica Complejo Hospitalario Sán Millán-San Pedro, Lardero, Spain.

出版信息

South Med J. 2002 May;95(5):542-4.

PMID:12005014

Abstract

BACKGROUND

This study was done to determine variables associated with infectious rhabdomyolysis (IRM).

METHODS

In this retrospective case-control study, rhabdomyolysis (RM) was defined as a fivefold or greater elevation in creatine kinase (CK) levels with a muscle/brain (MB) fraction <5%. Patients with myocardial infarction or cerebrovascular accident or a recent history of surgery, trauma, or immobilization were excluded.

RESULTS

We analyzed 52 cases of RM seen at our institution between 1992 and 2000; IRM was the most frequent cause (31%), most commonly respiratory tract infections (38%). When a microorganism could be identified (50%), it was more often gram-negative (63%). Patients with IRM were elderly and had fever and lower CK levels. Infectious rhabdomyolysis was associated with a higher morbidity but not with a higher risk of death.

CONCLUSIONS

Infectious rhabdomyolysis is the main cause of RM and must be suspected in elderly patients with fever and low levels of CK.

摘要

背景

本研究旨在确定与感染性横纹肌溶解症（IRM）相关的变量。

方法

在这项回顾性病例对照研究中，横纹肌溶解症（RM）被定义为肌酸激酶（CK）水平升高五倍或更多，且肌肉/脑（MB）分数<5%。排除心肌梗死、脑血管意外患者或近期有手术、创伤或制动史的患者。

结果

我们分析了1992年至2000年间在我们机构就诊的52例RM患者；IRM是最常见的病因（31%），最常见的是呼吸道感染（38%）。当能够鉴定出微生物时（50%），革兰氏阴性菌更为常见（63%）。IRM患者年龄较大，有发热症状且CK水平较低。感染性横纹肌溶解症与较高的发病率相关，但与较高的死亡风险无关。