Blanco José Ramón, Zabalza Marta, Salcedo Javier, Echeverria Lorenzo, García Ana, Vallejo Manuel
Servicio de Medicina Interna y Documentación Clínica Complejo Hospitalario Sán Millán-San Pedro, Lardero, Spain.
South Med J. 2002 May;95(5):542-4.
This study was done to determine variables associated with infectious rhabdomyolysis (IRM).
In this retrospective case-control study, rhabdomyolysis (RM) was defined as a fivefold or greater elevation in creatine kinase (CK) levels with a muscle/brain (MB) fraction <5%. Patients with myocardial infarction or cerebrovascular accident or a recent history of surgery, trauma, or immobilization were excluded.
We analyzed 52 cases of RM seen at our institution between 1992 and 2000; IRM was the most frequent cause (31%), most commonly respiratory tract infections (38%). When a microorganism could be identified (50%), it was more often gram-negative (63%). Patients with IRM were elderly and had fever and lower CK levels. Infectious rhabdomyolysis was associated with a higher morbidity but not with a higher risk of death.
Infectious rhabdomyolysis is the main cause of RM and must be suspected in elderly patients with fever and low levels of CK.
本研究旨在确定与感染性横纹肌溶解症（IRM）相关的变量。
在这项回顾性病例对照研究中，横纹肌溶解症（RM）被定义为肌酸激酶（CK）水平升高五倍或更多，且肌肉/脑（MB）分数<5%。排除心肌梗死、脑血管意外患者或近期有手术、创伤或制动史的患者。
我们分析了1992年至2000年间在我们机构就诊的52例RM患者；IRM是最常见的病因（31%），最常见的是呼吸道感染（38%）。当能够鉴定出微生物时（50%），革兰氏阴性菌更为常见（63%）。IRM患者年龄较大，有发热症状且CK水平较低。感染性横纹肌溶解症与较高的发病率相关，但与较高的死亡风险无关。
感染性横纹肌溶解症是RM的主要病因，对于发热且CK水平低的老年患者必须怀疑该病。
