Allan Iain, Newman Hubert, Wilson Michael
Department of Microbiology, Eastman Dental Institute, London, UK.
Clin Oral Implants Res. 2002 Feb;13(1):53-8. doi: 10.1034/j.1600-0501.2002.130106.x.
45S5 Bioglass is a bioactive implant material which, in its particulate form, is used in the repair of periodontal defects. The surface reactions undergone by this material in an aqueous environment may exert an antibacterial effect that would be beneficial to periodontal surgical treatment. Biofilms of Streptococcus sanguis, an early plaque former, and mixed species biofilms from a salivary inoculum grown under conditions similar to those associated with periodontal implants, were grown on particulate Bioglass in a constant depth film fermenter (CDFF). Control biofilms were grown on inert glass particulates. At sample times of 3, 24 and 48 hours the viability of biofilms of S. sanguis grown on Bioglass was significantly lower than for those grown on inert glass. In the experiments with subgingivally-modelled mixed species biofilms, the total anaerobic counts were significantly lower on Bioglass after 24 and 48 hours, but not 96 or 168 hours, compared to inert glass. Thus, particulate Bioglass has the potential to reduce bacterial colonisation of its surface in vivo, a feature relevant to post-surgical periodontal wound healing.
45S5生物活性玻璃是一种生物活性植入材料，其颗粒形式用于修复牙周缺损。该材料在水环境中发生的表面反应可能产生抗菌作用，这对牙周手术治疗有益。在恒定深度膜发酵罐（CDFF）中，在颗粒状生物活性玻璃上培养了早期菌斑形成菌血链球菌的生物膜以及在与牙周植入物相关的类似条件下生长的唾液接种物混合菌种生物膜。对照生物膜在惰性玻璃颗粒上生长。在3、24和48小时的采样时间，在生物活性玻璃上生长的血链球菌生物膜的活力明显低于在惰性玻璃上生长的生物膜。在龈下模拟混合菌种生物膜的实验中，与惰性玻璃相比，24和48小时后生物活性玻璃上的总厌氧菌数明显较低，但96或168小时后并非如此。因此，颗粒状生物活性玻璃有可能减少其在体内表面的细菌定植，这一特性与牙周手术后伤口愈合相关。
