Stoor P, Söderling E, Salonen J I
Institute of Dentistry, University of Turku, and Turku Centre for Biomaterials, Finland.
Acta Odontol Scand. 1998 Jun;56(3):161-5. doi: 10.1080/000163598422901.
Bioactive glasses contain oxides of calcium, sodium, phosphorus, and silicon in a proportion that provides the material with surface activity and concomitantly with the property of forming a strong bond with bone. Bioactive glasses have been tested as bone substitutes in different clinical situations. In an aqueous environment, Ca2+, Na+, PO4(3-) , and Si4+ are released from the glass, resulting in a rise in pH and in osmotic pressure in its vicinity. Since these are factors that potentially influence the viability of oral microorganisms at the dentogingival margin, we studied the effects of bioactive glass S53P4 on the oral microorganisms Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Actinomyces naeslundii, Streptococcus mutans, and Streptococcus sanguis. This was done by incubating each microbe in a suspension, in the presence of bioactive glass S53P4 in powder form. A. naeslundii was found to lose its viability within 10 min under the experimental conditions. A. actinomycetemcomitans, P. gingivalis, and S. mutans lost their viability within 60 min. Also for S. sanguis a significant loss of viability was seen within 60 min, but it was the only microbe that had any viable cells left after 60 min. Thus, in aqueous solutions the powdered bioactive glass S53P4 appears to have a broad antimicrobial effect on microorganisms of both supra- and subgingival plaque. Consequently, it could be useful as an ingredient in tooth-care products that may have beneficial effects on oral health both from a cariologic and a periodontal point of view.
生物活性玻璃含有钙、钠、磷和硅的氧化物，其比例赋予材料表面活性，并使其具有与骨形成强键的特性。生物活性玻璃已在不同临床情况下作为骨替代物进行了测试。在水性环境中，Ca2+、Na+、PO4(3-)和Si4+从玻璃中释放出来，导致其附近的pH值和渗透压升高。由于这些是可能影响牙-龈边缘口腔微生物生存能力的因素，我们研究了生物活性玻璃S53P4对口腔微生物伴放线放线杆菌、牙龈卟啉单胞菌、内氏放线菌、变形链球菌和血链球菌的影响。这是通过将每种微生物在含有粉末状生物活性玻璃S53P4的悬浮液中培养来完成的。在实验条件下，发现内氏放线菌在10分钟内失去生存能力。伴放线放线杆菌、牙龈卟啉单胞菌和变形链球菌在60分钟内失去生存能力。对于血链球菌，在60分钟内也观察到生存能力的显著丧失，但它是60分钟后仍有存活细胞的唯一微生物。因此，在水溶液中，粉末状生物活性玻璃S53P4似乎对龈上和龈下菌斑的微生物都有广泛的抗菌作用。因此，它作为牙齿护理产品中的一种成分可能是有用的，从龋齿学和牙周学的角度来看，这可能对口腔健康有有益的影响。
