黄病毒血清学中的交叉反应性：一项旧发现的新启示？

Cross-reactivity in flavivirus serology: new implications of an old finding?

作者信息

Allwinn R, Doerr H W, Emmerich P, Schmitz H, Preiser W

机构信息

Institute for Medical Virology, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany.

出版信息

Med Microbiol Immunol. 2002 Mar;190(4):199-202. doi: 10.1007/s00430-001-0107-9.

DOI:10.1007/s00430-001-0107-9

PMID:12005333

Abstract

To investigate the influence of pre-existing antibodies against tick-borne encephalitis (TBE) or yellow fever (YF) viruses on dengue virus antibody test results, we examined sera from vaccinees and from individuals with previous TBE virus infection. Distinct IgG antibody cross-reactivity was found in about 15.1% in the YF-vaccinated group and in about 9.5% in the TBE-vaccinated group. Altogether 15 out of a total of 80 samples tested (18.8%) had detectable dengue virus IgG antibody titres. The serum samples from patients with acute TBE virus infection not only had the highest anti-TBE virus antibodies but were also highly cross-reactive against dengue virus antigens. The high cross-reactivity rate of YF and TBE antibody-positive sera in dengue virus antibody assays should be taken into account in the interpretation of laboratory tests for the diagnosis of flavivirus infections and when undertaking seroepidemiological surveys.

摘要

为研究既往针对蜱传脑炎（TBE）或黄热病（YF）病毒的抗体对登革病毒抗体检测结果的影响，我们检测了疫苗接种者以及既往感染过TBE病毒的个体的血清。在YF疫苗接种组中，约15.1%的样本发现有明显的IgG抗体交叉反应，在TBE疫苗接种组中这一比例约为9.5%。在总共检测的80个样本中，有15个（18.8%）检测到登革病毒IgG抗体滴度。急性TBE病毒感染患者的血清样本不仅具有最高的抗TBE病毒抗体，而且对登革病毒抗原也有高度交叉反应。在对黄病毒感染进行实验室诊断检测以及进行血清流行病学调查时，应考虑YF和TBE抗体阳性血清在登革病毒抗体检测中的高交叉反应率。