Stock Jeffry B, Levit Mikhail N, Wolanin Peter M
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Sci STKE. 2002 May 14;2002(132):pe25. doi: 10.1126/stke.2002.132.pe25.
Motile bacteria respond to attractants and repellents in their environment by changing their movement. Stock et al. describe the similarities of the bacterial chemotaxis signaling system to eukaryotic signaling cascades. Also included is a discussion of how the ordered signaling complex of the receptor, the kinase CheA, and the kinase regulator CheW can be thought of as a primitive "probrain" to allow the integration of signals to produce the optimal cellular response.
运动性细菌通过改变其运动方式来响应环境中的吸引剂和驱避剂。斯托克等人描述了细菌趋化信号系统与真核信号级联反应的相似性。其中还讨论了受体、激酶CheA和激酶调节因子CheW的有序信号复合物如何被视为一种原始的“原脑”,以便整合信号以产生最佳的细胞反应。