Dymock I W, Tucker J S, Woolf I L, Poller L, Thomson J M
Br J Haematol. 1975 Mar;29(3):385-95. doi: 10.1111/j.1365-2141.1975.tb01836.x.
A coagulation screen has been performed on 12 patients with acute liver failure. Six died and six recovered. All six fatal cases developed a haemorrhagic state with haemostatic failure. An attempt has been made to delineate the various mechanisms for the production of the coagulation defect. The significance of the different haematological parameters in assessing prognosis has been assessed. The study emphasizes the importance of the synthetic ability of the liver in determining survival prospects. A good correlation between the factor-VII level, which is a guide to liver synthesis, and recovery has been shown. The value of a specific factor-VII assay in acute liver failure appears considerable. Where this assay cannot be performed the clot opacity fibrinogen technique provides a reasonable guide to the prognosis. The presence or absence of DIC was not a determinant factor in survival in this series.
对12例急性肝衰竭患者进行了凝血检查。6例死亡，6例康复。所有6例致命病例均出现止血功能衰竭的出血状态。已尝试描述产生凝血缺陷的各种机制。评估了不同血液学参数在评估预后中的意义。该研究强调了肝脏合成能力在决定生存前景方面的重要性。已表明作为肝脏合成指标的凝血因子VII水平与康复之间存在良好的相关性。凝血因子VII特异性检测在急性肝衰竭中的价值似乎相当大。在无法进行该检测的情况下，凝块浊度纤维蛋白原技术可为预后提供合理的指导。在该系列中，弥散性血管内凝血的存在与否不是生存的决定因素。
