Green G, Dymock I W, Poller L, Thomson J M
Lancet. 1975 Jun 14;1(7920):1311-4. doi: 10.1016/s0140-6736(75)92317-x.
A prothrombin complex concentrate rich in factor VII has been used in the management of the clotting defect in thirteen patients with liver disease. Adequate correction of coagulation was achieved immediately after infusion in all cases. Within 4 hours there was some deterioration and by 24 hours the results approximated to pre-fusion values. Liver biopsies were performed without haemorrhagic complication in the immediate post-infusion period. There was no evidence of induced intravascular coagulation. Since other prothrombin complex concentrates have proved disappointing, both in their failure to correct the clotting defect and in their production of disseminated intravascular coagulation, this factor-VII-rich concentrate may be the treatment of choice in patients with liver disease who require temporary correction of their coagulation defect.
一种富含凝血因子VII的凝血酶原复合物浓缩剂已用于治疗13例肝病患者的凝血缺陷。所有病例在输注后均立即实现了凝血的充分纠正。4小时内出现了一些恶化，到24小时时结果接近输注前值。在输注后即刻进行肝活检未出现出血并发症。没有证据表明诱发了血管内凝血。由于其他凝血酶原复合物浓缩剂在纠正凝血缺陷及引发弥散性血管内凝血方面均令人失望，这种富含因子VII的浓缩剂可能是需要临时纠正凝血缺陷的肝病患者的首选治疗方法。
