Oyama T, Maeda A, Jin J, Satone T, Kudo M
Br J Anaesth. 1975 Aug;47(8):837-40. doi: 10.1093/bja/47.8.837.
The effects of althesin on adrenocortical and thyroid function were investigated by measuring plasma concentrations of cortisol, thyroxine (T4) and free thyroxine index (FTI) in 29 surgical patients. Althesin did not change the plasma cortisol concentrations from the preanaesthetic control value; however, the concentrations increased significantly after the start of surgery and thereafter. Althesin anaesthesia per se decreased slightly, but significantly, plasma T4 concentration, but did not influence the FTI value. The surgical operation increased the FTI value slightly but significantly. Our data would suggest that Althesin anaesthesia can be used in patients who have abnormal adrenocortical or thyroid activity.
通过测量29例外科手术患者血浆中皮质醇、甲状腺素（T4）和游离甲状腺素指数（FTI）的浓度，研究了阿法沙龙对肾上腺皮质和甲状腺功能的影响。阿法沙龙并未使血浆皮质醇浓度偏离麻醉前对照值；然而，手术开始后及之后，皮质醇浓度显著升高。阿法沙龙麻醉本身使血浆T4浓度略有但显著降低，但不影响FTI值。外科手术使FTI值略有但显著升高。我们的数据表明，阿法沙龙麻醉可用于肾上腺皮质或甲状腺功能异常的患者。
