Ishikawa T, Wakuta K, Kanda K, Okuda Y
Br J Anaesth. 1976 Nov;48(11):1083-86. doi: 10.1093/bja/48.11.1083.
Blood from non-smoking donors was incubated with Althesin and the PO2 for half-saturation of haemoglobin at standard pH, PCO2 and temperature (P 50) was measured. The mean P 50 values of blood with blood concentrations of Althesin of 0.14 ml/dl and 0.42 ml/dl were greater (1.14 +/- 0.31 (SEM) mm Hg (P less than 0.005) and 2.22 +/- 0.35 (SEM) mm Hg (P less than 0.001), respectively) than that of control blood. These increases were dose-dependent (P less than 0.05). Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) concentrations were not significantly different between the Althesin-treated and the control blood. Although a decrease in the affinity of haemoglobin for oxygen in vitro in the presence of Althesin was statistically significant, this would have no clinical significance if the drug was being used for the induction of anaesthesia only.
将非吸烟献血者的血液与阿耳忒辛一起孵育，并测量在标准pH、PCO₂和温度下血红蛋白半饱和时的PO₂（P50）。阿耳忒辛血液浓度为0.14 ml/dl和0.42 ml/dl时血液的平均P50值分别比对照血液的平均P50值更高（分别为1.14±0.31（SEM）mmHg（P<0.005）和2.22±0.35（SEM）mmHg（P<0.001））。这些增加呈剂量依赖性（P<0.05）。阿耳忒辛处理的血液和对照血液之间的红细胞2,3-二磷酸甘油酸（2,3-DPG）浓度没有显著差异。虽然在阿耳忒辛存在下体外血红蛋白对氧的亲和力降低具有统计学意义，但如果该药物仅用于诱导麻醉，则这没有临床意义。
