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离体灌注大鼠心脏的心室颤动阈值与易损期

Ventricular fibrillation threshold and vulnerable period in the isolated perfused rat heart.

作者信息

Lubbe W F, Bricknell O L, Marzagao C

出版信息

Cardiovasc Res. 1975 Sep;9(5):613-20. doi: 10.1093/cvr/9.5.613.

DOI:10.1093/cvr/9.5.613
PMID:1201569
Abstract

Ventricular fibrillation threshold (VFT) measurements were obtained in the isolated perfused rat heart. Detailed morphology of the vulnerable period (VP) could be described by stimulating repeatedly at increasing levels of stimulus energy. Addition of lignocaine to the system caused an elevation of VGT, but also led to a delay of the VP to the end of the QT interval. The implications of these findings for the understanding of VFT measurements are discussed.

摘要

在离体灌注大鼠心脏中进行心室颤动阈值(VFT)测量。通过以递增的刺激能量水平反复刺激,可以描述易损期(VP)的详细形态。向系统中添加利多卡因会导致VGT升高,但也会使VP延迟至QT间期结束。讨论了这些发现对理解VFT测量的意义。

相似文献

1
Ventricular fibrillation threshold and vulnerable period in the isolated perfused rat heart.离体灌注大鼠心脏的心室颤动阈值与易损期
Cardiovasc Res. 1975 Sep;9(5):613-20. doi: 10.1093/cvr/9.5.613.
2
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引用本文的文献

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Chronophysiological view on changes of the electrical stability of the heart and heart rate under pentobarbital sodium and ketamine/xylazine anesthesia in a hypoventilation-reoxygenation rat model.戊巴比妥钠和氯胺酮/赛拉嗪麻醉下低通气-复氧大鼠模型中心脏电稳定性和心率变化的时间生理学观点
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2
The effect of hypoxic myocardial preconditioning is highly dependent on the light-dark cycle in Wistar rats.低氧心肌预处理的效果高度依赖于Wistar大鼠的昼夜节律。
Exp Clin Cardiol. 2008 Winter;13(4):204-8.
3
Development of a severe model of early coronary artery ligation-induced dysrhythmias in the anaesthetized rat.
麻醉大鼠早期冠状动脉结扎诱发心律失常严重模型的建立。
Br J Pharmacol. 1981 Aug;73(4):951-9. doi: 10.1111/j.1476-5381.1981.tb08750.x.
4
The effects of lidocaine on the ventricular fibrillation threshold and primary ventricular fibrillation following acute experimental coronary occlusion.利多卡因对急性实验性冠状动脉闭塞后室颤阈值及原发性室颤的影响。
Basic Res Cardiol. 1981 Jan-Feb;76(1):29-43. doi: 10.1007/BF01908161.
5
Blood cardioplegia delivery. Deleterious effects of potassium versus lidocaine.血液心脏停搏液的输注。钾与利多卡因的有害影响。
Ann Surg. 1983 Sep;198(3):266-72. doi: 10.1097/00000658-198309000-00003.
6
Changes in the incidence and duration of ventricular fibrillation in dependence on the extraneuronal accumulation of isoprenaline in the perfused rat heart.在灌注大鼠心脏中,室颤发生率和持续时间的变化取决于异丙肾上腺素在神经外的蓄积情况。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Oct;331(1):76-81. doi: 10.1007/BF00498854.
7
The effect of calcium concentration on spontaneous ventricular defibrillation and VF threshold.
Basic Res Cardiol. 1987 Jul-Aug;82(4):405-10. doi: 10.1007/BF01907028.
8
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Basic Res Cardiol. 1988 Nov-Dec;83(6):678-86. doi: 10.1007/BF01906963.
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